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Table 3 Comparison of nominal and non-nominal characteristics of patients divided into two time cohorts

From: Intracranial otogenic complications in adults: new factors that influenced its onset, frequency and nature

 

Time cohort

OR (95% CI)

Probability

Pre-COVID-19

COVID-19

Sex

    

Male

5 (100%)

8 (88.9%)

0.56 (0.02; 15.06)

p = 1*

Female

0

1 (11.1%)

  

Venous sinus thrombosis

    

Absent

4 (80%)

4(44.4%)

5 (0.38; 64.38)

p = 0.3

Present

1 (20%)

5 (55.6%)

  

Comorbidities

    

Other

1 (20%)

0

N/A

p = 0.002**

Cardiovascular

1 (20%)

5 (55.6%)

  

Pulmonary

1 (20%)

2 (22.2%)

  

None

2 (40%)

2 (22.2%)

  

Intracranial complications

    

Meningitis

2 (40%)

1 (11.1%)

N/A

p = 0. 0.009**

Brain abscess

2 (40%)

3 (33.3%)

  

Venous sinus thrombosis

0

2 (22.2%)

  

Brain abscess or meningitis with sinus thrombosis

1 (20%)

3 (33.3%)

  

Prior history of chronic otitis

    

Yes

3 (60%)

5 (55.56%)

1.2 (0.13; 11.05)

p = 1F

No

2 (40%)

4 (44.4%)

  

Risk factors for coagulopathies

    

Yes

1 (25%)

7 (12.5%)

0.05 (0.002; 1.04)

p = 0.067F

No

3 (75%)

1 (87.5%)

  
 

Median (IQR)

Median (IQR)

  

Age

32 (19)

50 (22)

N/A

p = 0.547UM

PT

14.75 (1.35)

15.1 (3)

N/A

p = 0.699UM

INR

1.35 (0.13)

1.39 (0.29)

N/A

p = 0.643UM

APTT

31 (2.5)

32 (7)

N/A

p = 0.816UM

WBC

16.63 (4.92)

16.45 (6.07)

N/A

p = 0.699UM

PLT

235 (224)

377 (399)

N/A

p = 0.316UM

Fibrinogen

273 (378.5)

336 (299)

N/A

p = 0.316UM

D-dimers

0.12 (0.56)

0.77 (1.3)

N/A

p = 0.247UM

CRP

111.05 (164.8)

147.4(180.8)

N/A

p = 0.758UM

LDH

134.5 (127)

177 (44)

N/A

p = 0.316UM

Total number of patients

N = 5

N = 9

  
  1. Underline values indicate significant (p < 0.05)
  2. N/A – not applicable; IQR – Interquartile ratio; OR – Odds Ratio; 95% CI – Confidence Interval; PT – prothrombin time; INR – International normalised ratio; APTT – activated partial thromboplastin time; WBC – White Blood Cell Count; PLT – Platelets; CRP – C-reactive protein levels; LDH – Lactic Acid Dehydrogenase
  3. *Haldane-Anscombe correction to Fisher’s exact test was applied
  4. **Fisher’s exact test after Haldane-Anscombe correction with Freeman-Halton extension for 2 × 4 contingency tables was used
  5. FFisher’s exact test was used
  6. UMMann–Whitney U test for non-parametric data was utilised