Table 1 Aggressive features, relative risk of aggressiveness and pathological size in BRAFV600E and RAS-like mutations
BRAFV600E (n = 117) | RAS (n = 97) | |
|---|---|---|
Age in years (SD) | 45.7 (13.5) | 49.6 (13.6) |
Male, N (%) | 26 (22.2) | 24 (24.7) |
Bethesda score distribution, N (%) | ||
III | 6 (5.1) | 33 (34.0) |
IV | 1 (0.9) | 38 (39.2) |
V | 23 (19.7) | 17 (17.5) |
VI | 87 (74.4) | 7 (7.2) |
Histological subtypes, N (%) | ||
Papillary carcinoma | 117 (100) | 93 (95.9) |
Follicular carcinoma | 0 | 2 (2.1) |
Hurthle cell carcinoma Hurthle cell carcinoma | 0 | 2 (2.1) |
Any aggressive features, N (%) | 89 (76.1) | 9 (9.3) |
Aggressive features, N (%) | ||
ETE* | 32 (27.4) | 1 (1.0) |
LN+* | 66 (56.4) | 8 (8.2) |
Tall cell | 41 (35.0) | 0 0 |
Columnar | 2 (1.7) | 0 |
Hobnail | 10 (8.5) | 0 |
Number of co-existing aggressive features in a single tumor, N (%) | ||
None | 28 (23.9) | 88 (90.7) |
1 Feature | 44 (37.6) | 9 (9.3) |
2 Features | 32 (27.4) | 0 |
3 Features | 10 (8.5) 10 (8.5) | 0 |
4 Features | 2 (1.7) | 0 |
5 Features | 1 (0.9) | 0 |
Mean pathological size in cm (SD) | 1.55 (0.84) | 2.04 (0.31) |
Pathological size 0–1.00 cm, N (%) | 37 (31.7) | 18 (18.6) |
Pathological size 1.01–1.50 cm, N (%) | 33 (28.2) | 22 (22.7) |
Pathological size 1.51–2.00 cm, N (%) | 19 (16.2) | 17 (17.5) |
Pathological size > 2.01 cm, N (%) | 28 (23.9) | 40 (41.2) |