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Fig. 3 | Journal of Otolaryngology - Head & Neck Surgery

Fig. 3

From: LncRNA CASC15 upregulates cyclin D1 by downregulating miR-365 in laryngeal squamous cell carcinoma to promote cell proliferation

Fig. 3

CASC15 upregulated cyclin D1 by downregulating miR-365. The expression of CASC15, miR-365 and cyclin D1 were significantly upregulated at 24 h after transfections comparing to the two controls (*, One-way ANOVA and Tukey test, p = 0.013) (A). Overexpression of CASC15 resulted in downregulation of miR-365, while overexpression of miR-365 did not affect the expression of CASC15 (*, One-way ANOVA and Tukey test, p = 0.024) (B). Overexpression of CASC15 resulted in upregulation of cyclin D1, while overexpression of miR-365 resulted in downregulation of cyclin D1 and attenuated the effects of overexpression of CASC15 (*, One-way ANOVA and Tukey test, p < 0.038) (C). Moreover, overexpression of cyclin D1 affected the expression of neither CASC15 nor miR-365 (D), C, Blank control group, NC1, empty vector transfection, NC2, negative control miRNA transfection, (*, p < 0.05)

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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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