Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma

Table 2 Univariate analysis of factors impacting survival (n = 105)

Variable	Number	5-year OS^†	p	5-year DSS^‡	p	5-year DFS^§	p
Variable	Number	(%)	p	(%)	p	(%)	p
Sex
Male	91	77.2	0.780	80.8	0.233	66.6	0.310
Female	14	85.7		92.9		78.6
Age
< 54	50	85.7	0.140	85.7	0.134	71.9	0.281
≥ 54	55	71.8		79.3		65.0
Smoking habit
No	19	73.3	0.656	83.1	0.606	68.0	0.782
Yes	86	79.7		82.3		68.3
Betelnut chewing
No	22	71.0	0.603	85.2	0.511	72.4	0.473
Yes	83	80.3		81.5		67.1
Alcohol drinking
No	26	88.5	0.213	96.0	0.086	76.3	0.331
Yes	79	75.2		78.0		65.6
pT classification
pT1	28	96.4	0.004^*	96.4	0.021^*	84.6	0.023^*
pT2-3	77	72.2		77.3		62.3
Histological grade
WDSCC^¶	38	83.9	0.743	86.5	0.839	68.3	0.309
MDSCC^∥	62	75.0		80.1		70.6
PDSCC^#	5	80.0		80.0		40.0
Depth of invasion
< 8 mm	52	84.1	0.121	88.5	0.256	74.6	0.351
≥ 8 mm	53	73.0		76.6		62.1
Perineural invasion
No	71	77.7	0.528	80.9	0.405	64.3	0.128
Yes	34	79.3		85.3		76.2
Lymphovascular invasion
No	82	78.7	0.953	81.2	0.857	66.6	0.621
Yes	23	77.7		86.7		73.9
Surgical margin
< 4 mm	23	71.2	0.279	71.2	0.320	60.9	0.364
≥ 4 mm	82	80.1		85.2		70.3
Size of positive node
< 1.3 cm	42	83.1	0.431	88.1	0.224	75.8	0.182
≥ 1.3 cm	63	75.1		78.5		63.3
Adjuvant therapy
No	53	72.5	0.801	78.1	0.239	63.5	0.270
Yes	52	84.3		86.5		73.0

^†OS, overall survival; ^‡DSS, disease specific survival; ^§DFS, disease free survival
^¶WDSCC, well differentiated squamous cell carcinoma
^∥MDSCC, moderately differentiated squamous cell carcinoma
^#PDSCC, poorly differentiated squamous cell carcinoma