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Table 2 Univariate analysis of factors impacting survival (n = 105)

From: Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma

Variable Number 5-year OS p 5-year DSS p 5-year DFS§ p
(%) (%) (%)
Sex        
 Male 91 77.2 0.780 80.8 0.233 66.6 0.310
 Female 14 85.7   92.9   78.6  
Age        
 < 54 50 85.7 0.140 85.7 0.134 71.9 0.281
 ≥ 54 55 71.8   79.3   65.0  
Smoking habit        
 No 19 73.3 0.656 83.1 0.606 68.0 0.782
 Yes 86 79.7   82.3   68.3  
Betelnut chewing        
 No 22 71.0 0.603 85.2 0.511 72.4 0.473
 Yes 83 80.3   81.5   67.1  
Alcohol drinking        
 No 26 88.5 0.213 96.0 0.086 76.3 0.331
 Yes 79 75.2   78.0   65.6  
pT classification        
 pT1 28 96.4 0.004* 96.4 0.021* 84.6 0.023*
 pT2-3 77 72.2   77.3   62.3  
Histological grade        
 WDSCC 38 83.9 0.743 86.5 0.839 68.3 0.309
 MDSCC 62 75.0   80.1   70.6  
 PDSCC# 5 80.0   80.0   40.0  
Depth of invasion        
 < 8 mm 52 84.1 0.121 88.5 0.256 74.6 0.351
 ≥ 8 mm 53 73.0   76.6   62.1  
Perineural invasion        
 No 71 77.7 0.528 80.9 0.405 64.3 0.128
 Yes 34 79.3   85.3   76.2  
Lymphovascular invasion        
 No 82 78.7 0.953 81.2 0.857 66.6 0.621
 Yes 23 77.7   86.7   73.9  
Surgical margin        
 < 4 mm 23 71.2 0.279 71.2 0.320 60.9 0.364
 ≥ 4 mm 82 80.1   85.2   70.3  
Size of positive node        
 < 1.3 cm 42 83.1 0.431 88.1 0.224 75.8 0.182
 ≥ 1.3 cm 63 75.1   78.5   63.3  
Adjuvant therapy        
 No 53 72.5 0.801 78.1 0.239 63.5 0.270
 Yes 52 84.3   86.5   73.0  
  1. OS, overall survival; DSS, disease specific survival; §DFS, disease free survival
  2. WDSCC, well differentiated squamous cell carcinoma
  3. MDSCC, moderately differentiated squamous cell carcinoma
  4. #PDSCC, poorly differentiated squamous cell carcinoma