Fig. 5

Circ_0000144 sponged miR-1178-3p to regulate PTC cell proliferation, apoptosis, migration, invasion, and angiogenesis. A–K PTC cells were transfected with si-NC, si-circ_0000144, si-circ_0000144 + anti-miR-NC, or si-circ_0000144 + anti-miR-1178-3p. A–D CCK-8 and flow cytometry assays were conducted to analyze the proliferation and cell cycle progression of PTC cells. E Western blotting analyzed protein levels of cyclinD1 and p21 in PTC cells. F Flow cytometry assay detected the apoptotic rate of PTC cells. G Western blotting assessed protein levels of Bax and Bcl-2 in PTC cells. H–K The migration, invasion, and angiogenesis of PTC cells were determined by wound-healing, transwell, and tube formation assays. *P < 0.05 vs. si-NC or si-circ_0000144 + anti-miR-NC