Glucocorticoid receptor (NR3C1) genetic polymorphisms and the outcomes of sudden sensorineural hearing loss

Table 2 Associations of six single nucleotide polymorphisms (SNPs) of the NR3C1 gene with sudden sensorineural hearing loss (SSNHL)

SNP	Overall, n (%)		P value¹	Adjusted OR (95% CI)²	P value³
SNP	Poor	Good	P value¹	Adjusted OR (95% CI)²	P value³
rs12653301
Genotypes
GG	31 (33)	34 (34)	0.967	1.00⁴
AG	42 (45)	46 (46)		1.00 (0.52–1.9)	0.999
AA	20 (22)	20 (20)		1.91(0.41–2.01)	0.822
Alleles
G	104 (56)	114 (57)	0.830	1.00⁴
A	82 (44)	86 (43)		0.958 (0.64–1.43)	0.834
rs17100289
Genotypes
AA	28 (30)	37 (37)	0.003^*	1.00⁴
AT	54 (58)	36 (36)		0.50 (0.26–0.95)	0.035^*
TT	11 (12)	27 (27)		1.84 (0.79–4.46)	0.159
Alleles
A	110 (59)	110 (55)	0.412	1.00⁴
T	76 (41)	90 (45)		1.18 (0.79–1.78)	0.416
rs4912650
Genotypes
TT	36 (39)	40 (40)	0.917	1.00⁴
GT	42 (45)	46 (46)		0.99 (0.53–1.83)	0.963
GG	15 (16)	14 (14)		0.84 (0.35–1.98)	0.689
Alleles
T	114 (61)	126 (63)	0.729	1.00⁴
G	72 (39)	74 (37)		0.93 (0.62–1.40)	0.728
rs4912912
Genotypes
TT	24 (26)	36 (38)	0.030^*	1.00⁴
CT	53 (57)	38 (38)		0.47 (0.24–0.92)	0.026^*
CC	16 (17)	26 (26)		1.09 (0.49–2.47)	0.836
Alleles
T	101 (54)	110 (55)	0.890	1.00⁴
C	85 (46)	90 (45)		0.97 (0.65–1.45)	0.891
rs6877893
Genotypes
AA	54 (58)	57 (57)	0.988	1.00⁴
AG	31 (33)	34 (34)		1.04 (0.56–1.92)	0.903
GG	8 (9)	9 (9)		1.07 (0.38–3.03)	0.904
Alleles
A	139 (75)	148 (74)	0.869	1.00⁴
G	47 (25)	52 (26)		1.04 (0.66–1.64)	0.871
rs9324924
Genotypes
GG	32 (34)	32 (32)	0.931	1.00⁴
GT	49 (53)	54 (54)		1.11 (0.59–2.07)	0.754
TT	12 (13)	14 (14)		1.17 (0.47–2.98)	0.732
Alleles
G	113 (61)	118 (59)	0.726	1.00⁴
T	73 (39)	82 (41)		1.08 (0.72–1.62)	0.717

ISSN: 1916-0216