Table 1 Demographic and clinical characteristics of study patients, n = 116
From: Prognostic stratification of oropharyngeal cancer patients in a betel nut chewing and low HPV area
Variable | All (n = 116) | p16− (n = 91) | p16 + (n = 25) | P value |
|---|---|---|---|---|
Age (Mean ± SD) | 57.3 ± 9.9 | 57.2 ± 10.5 | 57.8 ± 7.1 | 0.744 |
Sex | < 0.001 | |||
Female | 13 (11.2) | 5 (5.5) | 8 (32.0) | |
Male | 103 (88.8) | 86 (94.5) | 17 (68.0) | |
Alcohol | 84 (72.4) | 69 (75.8) | 15 (60.0) | 0.117 |
Betel nuts | 84 (72.4) | 72 (79.1) | 12 (48.0) | 0.002 |
Cigarettes | 77 (66.4) | 66 (72.5) | 11 (44.0) | 0.007 |
High PD-L1 (CPS ≥ 20) | 45 (38.8) | 31 (34.1) | 14 (56.0) | 0.046 |
P53 mutant (≥ 80%) | 22 (19.0) | 20 (22.0) | 2 (8.0) | 0.114 |
High EGFR expression (H score ≥ 200) | 34 (29.3) | 30 (33) | 4 (16) | 0.099 |
Tumor subsite | 0.004 | |||
Tonsil | 47 (40.5) | 29 (31.9) | 18 (72.0) | |
Soft palate | 35 (30.2) | 32 (35.2) | 3 (12.0) | |
Tongue base | 27 (23.2) | 23 (25.2) | 4 (16.0) | |
Others* | 6 (5.1) | 6(6.6) | 0 | |
Differentiation | 0.068 | |||
Well/moderately | 86 (74.1) | 71 (78.0) | 15 (60.0) | |
Poorly | 30 (25.9) | 20 (22.0) | 10 (40.0) | |
Treatment | 0.008 | |||
Operation | 59 (50.9) | 53 (58.2) | 6 (24.0) | |
CCRT/RT | 33 (28.4) | 21 (23.1) | 12 (48.0) | |
IC-based treatment** | 24 (20.7) | 17 (18.7) | 7 (28.0) | |
cT classification | 0.199 | |||
T1 | 42 (36.2) | 33 (36.3) | 9 (36.0) | |
T2 | 38 (32.8) | 28 (30.8) | 10 (40.0) | |
T3 | 11 (9.5) | 7 (7.7) | 4 (16.0) | |
T4 | 25 (21.6) | 23 (25.3) | 2 (8.0) | |
cN classification | 0.086 | |||
N0 | 61 (52.6) | 53 (58.2) | 8 (32.0) | |
N1 | 6 (5.2) | 4 (4.4) | 2 (8.0) | |
N2 | 47 (40.5) | 32 (35.2) | 15 (60.0) | |
N3 | 2 (1.7) | 2 (2.2) | 0 (0.0) | |
cStage | 0.255 | |||
I | 30 (25.9) | 25 (27.5) | 5 (20.0) | |
II | 26 (22.4) | 23 (25.3) | 3 (12.0) | |
III | 8 (6.9) | 5 (5.5) | 3 (12.0) | |
IV | 52 (44.8) | 38 (41.8) | 14 (56.0) | |
Extranodal extension*** | 32 (29.1) | 22 (25.6) | 10 (41.7) | 0.125 |