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  1. HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. ...

    Authors: Faisal Alzahrani, Leanne Clattenburg, Shanmugam Muruganandan, Martin Bullock, Kaitlyn MacIsaac, Michael Wigerius, Blair A. Williams, M. Elise R. Graham, Matthew H. Rigby, Jonathan R. B. Trites, S. Mark Taylor, Christopher J. Sinal, James P. Fawcett and Robert D. Hart
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:15
  2. Medialization thyroplasty and injection laryngoplasty are widely accepted treatment options for unilateral vocal fold paralysis. Although both procedures result in similar clinical outcomes, little is known ab...

    Authors: Samantha Tam, Hongmei Sun, Sisira Sarma, Jennifer Siu, Kevin Fung and Leigh Sowerby
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:14
  3. Otolaryngology-Head and Neck surgery resident physicians (OHNSR) have a high prevalence of burnout, job dissatisfaction and stress as shown within the literature. Formal mentorship programs (FMP) have a proven...

    Authors: Han Zhang, Andre Isaac, Erin D. Wright, Yaser Alrajhi and Hadi Seikaly
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:13
  4. Adenotonsillectomy is the most commonly performed operation for pediatric snoring/sleep disordered breathing (S/SDB). However, 20–40% of patients will fail to improve. Drug-induced sleep endoscopy (DISE) may p...

    Authors: Malak Jamal Gazzaz, André Isaac, Scott Anderson, Noura Alsufyani, Yaser Alrajhi and Hamdy El-Hakim
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:12
  5. Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopatholog...

    Authors: Natasha Cohen, Michael Gupta, Lilian Doerwald-Munoz, Dan Jang, James Edward Massey Young, Stuart Archibald, Bernard Jackson, Jenny Lee and Max Chernesky
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:11
  6. The objective of this study was to validate our approach of treating primary hyperparathyroidism using sestamibi scan directed parathyroidectomy, without routine use of intraoperative parathyroid hormone measu...

    Authors: Alexandra Thielmann and Paul Kerr
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:10
  7. Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-c...

    Authors: Cameron Lindsay, Hadi Seikaly and Vincent L. Biron
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:9
  8. The midline and paramedian mandibulotomy are surgical procedures that divide the mandibular bone into two halves and disconnects the condylar heads of the TMJ from each other. This study aimed to prospectively...

    Authors: Mohammed A. Q. Al-Saleh, Kumaradevan Punithakumar, Manuel Lagravere, Pierre Boulanger, Jacob L. Jaremko, John Wolfaardt, Paul W. Major and Hadi Seikaly
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:8
  9. Bacteria are suspected players in the pathogenesis of chronic rhinosinusitis (CRS), yet their exact role is not understood. We investigated the effect of planktonic and biofilm of staphylococcus aureus (SA) an...

    Authors: Almoaidbellah Rammal, Marc Tewfik and Simon Rousseau
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:7
  10. Passive transcutaneous osseointegrated hearing implant systems have become increasingly popular more recently. The area over the implant is vulnerable due to vibration and pressure from the externally worn sou...

    Authors: Adam Perenyi, Zsofia Bere, Janos Jarabin, Balazs Sztano, Edit Kukla, Ziad Bikhazi, Laszlo Tiszlavicz, Ferenc Toth, Jozsef Geza Kiss and Laszlo Rovo
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:6
  11. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by oncogenic human papillomavirus (HPV) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV E6 and E7 oncoproteins or by...

    Authors: Andre Isaac, Morris Kostiuk, Han Zhang, Cameron Lindsay, Fawaz Makki, Daniel A. O’Connell, Jeffrey R. Harris, David W. J. Cote, Hadi Seikaly and Vincent L. Biron
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:5
  12. We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement.

    Authors: Joanne Kim, Gilad Horowitz, Michael Hong, Mario Orsini, Sylvia L. Asa and Kevin Higgins
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:4
  13. Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection o...

    Authors: Jason K. Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten and Stephanie Johnson-Obaseki
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:3

    The Correction to this article has been published in Journal of Otolaryngology - Head & Neck Surgery 2018 47:49

  14. Bell´s palsy is the most common cause of facial paralysis worldwide and the most common disorder of the cranial nerves. It is a diagnosis of exclusion, accounting for 60–75% of all acquired peripheral facial n...

    Authors: S. K. Mueller, H. Iro, M. Lell, F. Seifert, C. Bohr, C. Scherl, A. Agaimy and M. Traxdorf
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:1
  15. The conventional technique for cancer resection margin analysis studies only 0.1% of the surgical margins. Complete frozen section margins - also known as Mohs margins – allows for analysis of 100% of the surg...

    Authors: Mathieu Bergeron, Pierre Gauthier and Nathalie Audet
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:63
  16. The majority of chemoradiation (CRT) trials for locally advanced head and neck squamous cell carcinoma (HNSCC) have relied on platinum-based chemotherapy regimens administered every-3-weeks. However, given the...

    Authors: James M. Melotek, Benjamin T. Cooper, Matthew Koshy, Joshua S. Silverman and Michael T. Spiotto
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:62
  17. Neck metastasis is the most important prognostic factor in oral cavity squamous cell carcinomas (SCC). Apart from the T- stage, depth of invasion has been used as a highly predictable factor for microscopic ne...

    Authors: H. A. Alsaffar, D. P. Goldstein, E. V. King, J. R. de Almeida, D. H. Brown, R. W. Gilbert, P J. Gullane, O. Espin-Garcia, W. Xu and J. C. Irish
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:61
  18. Binostril endoscopic transsphenoidal approach (BETA) provides sufficient manipulation space and wide endoscopic vision, although it increases the trauma of nose. Mononostril endoscopic transsphenoidal approach...

    Authors: Guodao Wen, Chao Tang, Chunyu Zhong, Junyang Li, Zixiang Cong, Yuan Zhou, Kaidong Liu, Yong Zhang, Mamatemin Tohti and Chiyuan Ma
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:60
  19. Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the s...

    Authors: Jérôme R. Lechien, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies and Sven Saussez
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:59
  20. Long operating time and high blood loss contribute to post-surgical morbidity. Therefore, strategies to reduce these factors should to be tested using robust methods.

    Authors: Dieter K. Fritz, T. Wayne Matthews, Shamir P. Chandarana, Steven C. Nakoneshny and Joseph C. Dort
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:58
  21. To describe the process involved in developing a decision aid prototype for parents considering adenotonsillectomy for their children with sleep disordered breathing.

    Authors: Erin Maguire, Paul Hong, Krista Ritchie, Jeremy Meier, Karen Archibald and Jill Chorney
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:57
  22. To explore the feasibility, the efficacy, and the mechanism of mandibular advancement devices (MAD) in the treatment of persistent sleep apnea after surgery.

    Authors: Huiping Luo, Xulan Tang, Yuanping Xiong, Lili Meng, Hongliang Yi and Shankai Yin
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:56
  23. Indications for performing a prophylactic central neck dissection (pCND) in papillary thyroid cancer (PTC) remain controversial. It is unclear how identification of lymph node (LN) metastases should impact the...

    Authors: Michael W. Deutschmann, Laura Chin-Lenn, Steven C. Nakoneshny, Joseph C. Dort, Janice L. Pasieka and Shamir P. Chandarana
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:55
  24. In recent decades, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising worldwide as a result of increasing oncogenic human papillomavirus (HPV) infections in the oropharynx. EZH2 is ...

    Authors: Sherif Idris, Cameron Lindsay, Morris Kostiuk, Colin Andrews, David W. J. Côté, Daniel A. O’Connell, Jeffrey Harris, Hadi Seikaly and Vincent L. Biron
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:54
  25. Ectopic parathyroid adenomas can occur in numerous anatomic locations. While ectopic parathyroid adenomas can rarely occur in the pharyngeal region, this has not previously been described in the soft palate.

    Authors: Brent A. Chang, Anil Sharma and Donald W. Anderson
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:53
  26. Management decisions are not straightforward when the Ultrasound Guided Fine Needle Aspiration (USFNA) demonstrates a Bethesda score of either category III or IV, and a diagnostic hemi-thyroidectomy or a repea...

    Authors: Alborz Jooya, Joe Saliba, Audrey Blackburn, Michael Tamilia, Michael P. Hier, Alex Mlynarek, Véronique-Isabelle Forest, Louise Rochon, Anca Florea, Hangjun Wang and Richard J. Payne
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:51
  27. A commonly employed treatment for advanced staged oropharyngeal squamous cell carcinoma (OPSCC) is concurrent radiation and chemotherapy with cisplatin as the gold standard. Carboplatin is reported to have the...

    Authors: M. Roskies, E. Kay-Rivest, M. A. Mascarella, K. Sultanem, A. Mlynarek and M. Hier
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:50
  28. Hearing deficits in children are demonstrably negatively associated with language acquisition and cognition. Although universal neonatal hearing screening exists, it is not offered equally across Canada. Addit...

    Authors: Tina Hu, Katherine Stead, Terence Fu and Blake Papsin
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:49
  29. Deformity in the dental arc and facial skeleton by adenoid hypertrophy due to chronic mouth breathing is a well-known process. Most of the related studies have been based on cephalometric analyses. The aim of ...

    Authors: Cigdem Fırat Koca, Tamer Erdem and Tuba Bayındır
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:48
  30. Little is known regarding the etiology and genomic underpinnings of Oral Tongue Squamous Cell Carcinoma (OTSCC) in patients who lack traditional risk factors, yet the incidence is increasing. In particular, th...

    Authors: Daniel L. Faden, Sarah T. Arron, Chase M. Heaton, Joseph DeRisi, Andrew P. South and Steven J. Wang
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:47
  31. Mental practice, the cognitive rehearsal of a task in the absence of overt physical movement, has been successfully used in teaching complex psychomotor tasks including sports and music, and recently, surgical...

    Authors: Anne Conlin, Jane Lea, Manohar Bance, Neil Chadha, Shaun Kilty, Frederick Kozak, Julian Savage, Ravindar Sidhu, Joseph Chen and Brian D. Westerberg
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:46
  32. The Skull Base Inventory (SBI) was developed to assess the quality of life of patients undergoing endoscopic or open approaches for anterior and central skull base pathologies. In this study, we sought to esta...

    Authors: Soroush Larjani, Eric Monteiro, Ian Witterick, Allan Vescan, Gelareh Zadeh, Fred Gentili, David P. Goldstein and John R. de Almeida
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:45
  33. Gas pressure balance is essential for maintaining normal middle ear function. The mucosal surfaces of the middle ear, the mastoid air cell system (MACS), and the Eustachian tube (ET) play a critical role in th...

    Authors: James Belyea, Brandon Wickens and Manohar Bance
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:44
  34. Obstructive sleep apnea (OSA) is a common disorder, and continuous airway positive pressure (CPAP) is considered to be the gold standard of therapy. CPAP however is known to have problems with adherence, with ...

    Authors: Brian W. Rotenberg, Dorian Murariu and Kenny P. Pang
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:43
  35. The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total/partial laryngectomies, and concurrent radiation chemotherapy for patients with early lar...

    Authors: R. J. De Santis, I. Poon, J. Lee, I. Karam, D. J. Enepekides and K. M. Higgins
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:42
  36. Gastric pull up remains a popular reconstructive option for pharyngoesophagectomy defects extending to thoracic inlet. Gastric necrosis is a dreaded complication of gastric pull up reconstruction and few studi...

    Authors: Oleksandr Butskiy, Donald W. Anderson and Eitan Prisman
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:41
  37. Total laryngectomy (TL) is an appropriate oncologic operation for many patients with laryngeal cancer delivering excellent oncologic outcomes, however it remains beset with significant functional consequences....

    Authors: A. Foreman, R. J. De Santis, F. Sultanov, D. J. Enepekides and K. M. Higgins
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:40
  38. Cervical and ocular vestibular evoked myogenic potentials (c/oVEMPs) reflect otolith function. Up-to-date, there are no published reports on the systemic evaluation of otolith function in Ménière’s Disease (MD...

    Authors: Liang Chen, Hui Xu, Wu-qing Wang, Qing-quan Zhang, Qiao-ying Lv and Xi-cheng Song
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:39
  39. Many Canadians are affected by sensorineural hearing loss (SNHL) and those with severe or profound hearing loss may have poor hearing function despite optimized hearing aids. Cochlear implants (CI) offer effec...

    Authors: Gavin J. le Nobel, Euna Hwang, Adrian Wu, Sharon Cushing and Vincent Y. Lin
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:38
  40. Sonotubometry is a non-invasive means of assessing Eustachian tube (ET) function. Its interpretation remains a complex task with questionable results due to wide variation between trials. A study was conducted...

    Authors: Yaw Amoako-Tuffour, Philip Garland and Manohar Bance
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:37
  41. Patients with chronic rhinosinusitis (CRS) often have to endure significant wait times for endoscopic sinus surgery (ESS). The pyschiatric impact of placement on a waitlist for ESS has not been explored.

    Authors: Gordon Fung-Zak Tsang, Carmen L. McKnight, Laura Minhui Kim and John M. Lee
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:36
  42. Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to d...

    Authors: Sabin Filimon, Keith Richardson, Michael P. Hier, Michael Roskies and Alex M. Mlynarek
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:35
  43. The purpose of this study was to evaluate the functional and oncological outcomes of patients treated for T3 laryngeal squamous cell carcinoma. Specifically comparing transoral laser microsurgery and radiother...

    Authors: A. Butler, M. H. Rigby, J. Scott, J. Trites, R. Hart and S. M. Taylor
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:34
  44. The aim of this study is to present the development of a new technique to obtain 3D models using photogrammetry by a mobile device and free software, as a method for making digital facial impressions of patien...

    Authors: Rodrigo Salazar-Gamarra, Rosemary Seelaus, Jorge Vicente Lopes da Silva, Airton Moreira da Silva and Luciano Lauria Dib
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:33
  45. Salivary ductal carcinoma (SDC) of parotid gland is a rare and aggressive entity; accounting for 1–3 % of all malignant salivary gland tumors, 0.2 % of epithelial salivary gland neoplasms, 0.5 % of salivary gl...

    Authors: Khalid Hussain AL-Qahtani, Mutahir A. Tunio, Yasser Bayoumi, Venkada Manickam Gurusamy, Fahad Ahmed A. Bahamdain and Hanadi Fatani
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:32
  46. It has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether preoperative thyroglobulin ant...

    Authors: S. Hosseini, R. J. Payne, F. Zawawi, A. Mlynarek, M. P. Hier, M. Tamilia and V. I. Forest
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:31
  47. The purpose of the present review is to systematically and critically analyze the available literature regarding the importance, applicability, and practicality of (MRI), computerized tomography (CT) or cone-b...

    Authors: Mohammed A. Q. Al-Saleh, Noura A. Alsufyani, Humam Saltaji, Jacob L. Jaremko and Paul W. Major
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:30
  48. Ultrasound guided fine needle aspiration (USFNA) biopsies of thyroid nodules sometimes create a decision-making dilemma for surgeons as they may yield falsely benign results. The McGill Thyroid Nodule Score + ...

    Authors: Sarah Khalife, Sarah Bouhabel, Veronique-Isabelle Forest, Michael P. Hier, Louise Rochon, Michael Tamilia and Richard J. Payne
    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:29