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Table 3 ORN severity in relation to radiation modality, dose and time to diagnosis

From: Osteoradionecrosis of the mandible: a case series at a single institution

  Stage 1 Stage 2 Stage 3 p value
Radiation modality IMRT 4/4 IMRT 3/3 IMRT 1/5 p = 0.03*
Conventional 4/5
Radiation dose (Gy), mean ± SD § 52.5 ± 5 60 ± 0 59 ± 9.86 p = 0.312
Average time from radiation to diagnosis in months (range) 6.47 (3.0–12.0) 9.83 (6.0–11.9) 52.35 (9.0–129.6) p = 0.056
  1. Modality information is missing on 1 patient with Grade 1 and 1 patient with Grade 3 disease.
  2. § Dose information missing in 2 patients with Grade 3 and 1 patient with Grade 1 disease.
  3. * Freeman-Halton extension of the Fisher exact probability test.
  4. One-way Analysis of Variance (ANOVA).
  5. IMRT intensity modulated radiation therapy.
  6. SD standard deviation.