Table 1 Comaprison of clinicopathological and treatment characteristics of children and adult patients with differentiated thyroid carcinoma at presentation
Variables | Children with DTC (<18 years) | Young adults with DTC (19–25 years) | Adults with DTC (26–30 years) | P value |
|---|---|---|---|---|
(n =27) | (n =78) | (n =52) | ||
Age (years) | ||||
Mean/range/SD | 13.5 (5–18) ± 4.3 | 22.41 ± 3.3 | 27.5 ± 2.8 | 0.0001 |
<10 years | 8 (29.6) | 0 | 0 | |
11–18 years | 19 (70.4) | 0 | 0 | |
Gender, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
M | 7 (25.9) | 8 (10.3) | 8 (15.4) | 0.038 |
F | 20 (74.1) | 70 (89.7) | 44 (84.6) | 0.160 |
Tumor size (cm) | ᅟ | ᅟ | ᅟ | ᅟ |
Mean/range/SD | 2.8 (0.8–6.5) ± 1.36 | 2.8 (0.8–6.4) ±1.36 | 2.9 (0.4–6.5) ±1.62 | 0.653 |
Histology n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
Papillary | 27 (100) | 72 (92.3) | 51 (98.1) | 0.605 |
Follicular | 0 | 6 (7.7) | 1 (1.9) | |
T stage, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
T1 | 12 (44.4) | 27 (34.6) | 26 (50.0) | 0.860 |
T2 | 11 (40.8) | 34 (43.6) | 15 (28.9) | |
T3 | 4 (14.8) | 15 (19.2) | 10 (19.2) | |
T4 | 0 | 2 (2.6) | 1 (1.9) | |
N stage, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
N0 | 7 (25.9) | 42 (53.8) | 32 (61.5) | 0.012 |
N1 | 20 (74.1) | 36 (46.2) | 20 (38.5) | |
N1a | 9 (45.0) | 22 (61.1) | 11 (55.0) | |
N1b | 11 (55.0) | 14 (38.9) | 9 (45.0) | |
M stage, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
M0 | 26 (96.3) | 77 (98.7) | 52 (100) | 0.379 |
M1 | 1 (3.7) | 1 (1.3) | 0 | |
LVSI, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
Yes | 12 (44.4) | 27 (34.6) | 16 (30.7) | 0.031 |
No | 15 (55.6) | 51 (65.4) | 36 (69.3) | |
Multifocality, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
Yes | 9 (33.3) | 43 (55.2) | 32 (61.5) | 0.012 |
No | 18 (66.6) | 35 (44.8) | 20 (38.5) | |
Risk stratification, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
Low | 2 (7.4) | 17 (21.8) | 11 (21.1) | 0.003 |
Intermediate | 2 (7.4) | 23 (29.5) | 21 (40.4) | |
High | 23 (85.2) | 38 (48.7) | 20 (38.5) | |
Surgery, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
Total thyroidectomy | 23 (85.2) | 68 (87.2) | 44 (84.6) | 0.065 |
Near total thyroidectomy | 4 (14.8) | 10 (12.8) | 8 (15.4) | |
Neck dissection, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
No | 3 (11.1) | 25 (32.1) | 15 (28.8) | 0.047 |
Yes | 24 (88.9) | 53 (67.9) | 37 (71.2) | |
Central | 13 (54.2) | 30 (56.6) | 18 (48.6) | |
Lateral | 11 (45.8) | 23 (43.4) | 19 (51.4) | |
Adjuvant RAI therapy, n (%) | ᅟ | ᅟ | ᅟ | ᅟ |
No | 1 (3.7) | 7 (9.0) | 2 (3.8) | 0.460 |
Yes | 26 (96.3) | 71 (91.0) | 50 (96.2) | |
30 mCi | 0 | 4 (5.6) | 1 (2.0) | |
100 mCi | 7 (27.0) | 20 (28.2) | 19 (38.0) | |
150 mCi | 14 (53.8) | 36 (50.7) | 20 (40.0) | |
200 mCi | 5 (19.2) | 11 (15.5) | 10 (20.0) |