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Table 1 Comaprison of clinicopathological and treatment characteristics of children and adult patients with differentiated thyroid carcinoma at presentation

From: “Clinicopathological features and treatment outcomes of differentiated thyroid cancer in Saudi children and adults”

Variables Children with DTC (<18 years) Young adults with DTC (19–25 years) Adults with DTC (26–30 years) P value
(n =27) (n =78) (n =52)
Age (years)     
 Mean/range/SD 13.5 (5–18) ± 4.3 22.41 ± 3.3 27.5 ± 2.8 0.0001
  <10 years 8 (29.6) 0 0
  11–18 years 19 (70.4) 0 0
Gender, n (%)
 M 7 (25.9) 8 (10.3) 8 (15.4) 0.038
 F 20 (74.1) 70 (89.7) 44 (84.6) 0.160
Tumor size (cm)
 Mean/range/SD 2.8 (0.8–6.5) ± 1.36 2.8 (0.8–6.4) ±1.36 2.9 (0.4–6.5) ±1.62 0.653
Histology n (%)
 Papillary 27 (100) 72 (92.3) 51 (98.1) 0.605
 Follicular 0 6 (7.7) 1 (1.9)
T stage, n (%)
 T1 12 (44.4) 27 (34.6) 26 (50.0) 0.860
 T2 11 (40.8) 34 (43.6) 15 (28.9)
 T3 4 (14.8) 15 (19.2) 10 (19.2)
 T4 0 2 (2.6) 1 (1.9)
N stage, n (%)
 N0 7 (25.9) 42 (53.8) 32 (61.5) 0.012
 N1 20 (74.1) 36 (46.2) 20 (38.5)
 N1a 9 (45.0) 22 (61.1) 11 (55.0)
 N1b 11 (55.0) 14 (38.9) 9 (45.0)
M stage, n (%)
 M0 26 (96.3) 77 (98.7) 52 (100) 0.379
 M1 1 (3.7) 1 (1.3) 0
LVSI, n (%)
 Yes 12 (44.4) 27 (34.6) 16 (30.7) 0.031
 No 15 (55.6) 51 (65.4) 36 (69.3)
Multifocality, n (%)
 Yes 9 (33.3) 43 (55.2) 32 (61.5) 0.012
 No 18 (66.6) 35 (44.8) 20 (38.5)
Risk stratification, n (%)
 Low 2 (7.4) 17 (21.8) 11 (21.1) 0.003
 Intermediate 2 (7.4) 23 (29.5) 21 (40.4)
 High 23 (85.2) 38 (48.7) 20 (38.5)
Surgery, n (%)
 Total thyroidectomy 23 (85.2) 68 (87.2) 44 (84.6) 0.065
 Near total thyroidectomy 4 (14.8) 10 (12.8) 8 (15.4)
Neck dissection, n (%)
 No 3 (11.1) 25 (32.1) 15 (28.8) 0.047
 Yes 24 (88.9) 53 (67.9) 37 (71.2)
 Central 13 (54.2) 30 (56.6) 18 (48.6)
 Lateral 11 (45.8) 23 (43.4) 19 (51.4)
Adjuvant RAI therapy, n (%)
 No 1 (3.7) 7 (9.0) 2 (3.8) 0.460
 Yes 26 (96.3) 71 (91.0) 50 (96.2)
 30 mCi 0 4 (5.6) 1 (2.0)
 100 mCi 7 (27.0) 20 (28.2) 19 (38.0)
 150 mCi 14 (53.8) 36 (50.7) 20 (40.0)
 200 mCi 5 (19.2) 11 (15.5) 10 (20.0)
  1. N number, DTC differentiated thyroid cancers, SD standrad deviation, M male, F female, T tumor, N node, M metastasis, LVSI lymphovascular space invasion, RAI radioactive iodine, mCi millicurie