From: Weekly versus every-three-weeks platinum-based chemoradiation regimens for head and neck cancer
Ā | Every-3-weeks platinum | Weekly platinum | P-value | Every-3-weeks cisplatinum | Weekly carboplatinum | P-value |
---|---|---|---|---|---|---|
Ā | (Nā=ā144) | (Nā=ā68) | Ā | (Nā=ā138) | (Nā=ā52) | Ā |
RT timing | Ā | Ā | .05 | Ā | Ā | .18 |
āPost-operative | 44 (30.6%) | 30 (44.1%) | 44 (31.9%) | 22 (42.3%) | ||
āDefinitive | 100 (69.4%) | 38 (55.9%) | 94 (68.1%) | 30 (57.7%) | ||
Induction chemotherapy | Ā | Ā | .60 | Ā | Ā | .59 |
āYes | 41 (28.5%) | 17 (25.0%) | 37 (26.8%) | 16 (30.8%) | ||
āNo | 103 (71.5%) | 51 (75.0%) | 101 (73.2%) | 36 (69.2%) | ||
Post-radiation lymph node dissection | Ā | Ā | .42 | Ā | Ā | .47 |
āYes | 19 (13.2%) | 5 (7.4%) | 18 (13.0%) | 4 (7.7%) | ||
āNo | 81 (56.3%) | 33 (48.5%) | 76 (55.1%) | 26 (50.0%) | ||
āNot stated | 44 (30.6%) | 30 (44.1%) | 44 (31.9%) | 22 (42.3%) | ||
RT technique | Ā | Ā | .57 | Ā | Ā | 0.68 |
ā3D-conformal | 25 (17.4%) | 14 (20.6%) | 23 (16.7%) | 10 (19.2%) | ||
āIMRT | 119 (82.6%) | 54 (79.4%) | 115 (83.3%) | 42 (80.8%) | ||
Type of chemotherapy | Ā | Ā | <.001 | Ā | Ā | <.001 |
āCisplatin | 138 (95.8%)a | 16 (23.5%) | 138 (100.0%) | 0 (0.0%) | ||
āCarboplatin | 9 (6.3%) | 52 (76.5%) | 0 (0.0%) | 52 (100.0%) | ||
Alterations in RT course | Ā | Ā | .83 | Ā | Ā | .90 |
āNone | 82 (56.9%) | 40 (58.8%) | 78 (56.5%) | 31 (59.6%) | ||
āDelay | 43 (29.9%) | 21 (30.9%) | 41 (29.7%) | 15 (28.9%) | ||
āTruncations | 19 (13.2%) | 7 (10.3%) | 19 (13.8%) | 6 (11.5%) | ||
Chemotherapy dose modification | Ā | Ā | .44 | Ā | Ā | .55 |
āYes | 76 (52.8%) | 32 (47.1%) | 73 (52.9%) | 25 (48.1%) | ||
āNo | 68 (47.2%) | 36 (52.9%) | 65 (47.1%) | 27 (51.9%) |