Fig. 2

Pathology from the primary parathyroid lesion with FNA-related changes, and biomarker testing to confirm the absence of malignant features. The parathyroid is well delineated but has a central scar; there is hemorrhage and focal cystic change (top left). The tumor is intensely positive for Bcl-2 (top middle). Nuclear parafibromin is intact (top right). Staining identifies Rb in tumor cell nuclei (bottom left). Galectin-3 is not seen in tumor cells; endothelial cells provide an internal positive control (bottom middle). Cyclin D1 is expressed by the majority of the tumor cell nuclei (bottom right)