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Fig. 2 | Journal of Otolaryngology - Head & Neck Surgery

Fig. 2

From: Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Fig. 2

Patient 8 biopsy specimen with non-keratinizing oropharyngeal carcinoma compared with adjacent non-neoplastic mucosa. Red RNAscope® 2.5 HD in-situ hybridization (ISH) assay for HPV-HR18 E6/E7 mRNA performed on the non-keratinizing squamous cell carcinoma revealed strong red chromogenic cytoplasmic expression (4+ semi-quantitative score, see Table 2) in the tumor (lower right and middle, Frame a) and no expression in the adjacent non-neoplastic (upper left, Frame a). Contrast with the dapβ negative control in Frame b. (original magnification ×200 for Frames a and b)

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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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