Fig. 2

a Change in creatine clearance in the regimen groups after two courses (^*p < 0.0001 Student’s t-test). b The crystalloid-only regimen group was divided into with and without aprepitant groups. Change in creatine clearance in the magnesium-supplemented regimen group and crystalloid-only group with and without aprepitant after one course (^†p = 0.0298 Student’s t-test). c Change in creatine clearance in the three groups after two courses (^‡p < 0.0001, ^§p = 0.0026 Student’s t-test). ∆Ccr, difference in creatine clearance between chemotherapy courses