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Table 3 Results for hydrogen peroxide-based antiseptic preparations

From: Systematic review of ototoxic pre-surgical antiseptic preparations – what is the evidence?

Author, Year Population Intervention Control Outcome
R. Perez, 2003 [13] 22 Sand Rats a) Hydrogen peroxide 3% solution
Exposure time 5 days.
ABR and VsEP tested on day 8 after initial exposure
a) Saline as negative control
b) Gentamicin as positive control
a) ABR could not be tested in 3/12 animals. All remaining animals had elevated base line from 55 dB to 108 dB
b) VsEP could not be recorded in 5/12 animals. All remaining animals had a increased from baseline of mean latency time
ME Nader, 2007 [12] 18 Chinchillas Solution tested
a) Hydrogen peroxide 3% solution
Exposure time 5 min
ABR performed 1 day after exposure
Contralateral ear to experimental ear b) No difference of ABR from baseline recording prior to instillation of hydrogen peroxide.