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Table 2 Treatment characteristics and outcomes of patients experiencing locoregional recurrence (LRR) or distant metastasis (DM) as first recurrence of adenoid cystic carcinoma

From: Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma

  LRR (n = 20) p value DM (n = 16) p value
Treatment
 Surgery 10   5  
 Surgery + PORT 8   0  
 RT alone 1   4  
  CF-RT 1   0  
  SBRT 0   2  
  Palliative RT 0   2  
 Systemic therapy alone 1   1  
 Observation 0   6  
3-year PFS 82.1%   61.2%  
3-year PFS
 Low-risk 100% 0.15 80.0% 0.48
 High-risk 64.3%   44.4%  
3-year OS 73.3%   85.1%  
3-year OS
 Low-risk 87.5% 0.01 100% 0.03
 High-risk 62.3%   76.2%  
  1. CF-RT conventionally fractionated radiation therapy, RT radiation therapy, PFS progression-free survival, PORT post-operative radiation therapy, OS overall survival