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Table 4 Multivariate analysis of overall and disease-specific survival for patients with OPSCC patients treated with resection

From: Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

  5-year overall survival 5-year disease-specific survival
Parameter HR (95% CI) p value HR (95% CI) p value
HR-HPV DNA (Positive vs. negative) 0.46 (0.26–0.81) 0.007 0.41 (0.18–0.90) 0.027
p16INK4a (High vs. low) 0.23 (0.16–0.57) < 0.001 0.22 (0.09–0.52) 0.001
pRB (High vs. low) 2.54 (1.46–4.41) 0.001 3.20 (1.46–6.99) 0.004
Cyclin D1 (High vs. low) 1.59 (0–2.55) 0.053 1.55 (0.82–2.94) 0.18
p53 (High vs. low) 1.79 (1.12–2.86) 0.015 1.52 (0.80–2.87) 0.20
High p16INK4a/HR-HPV DNA positive vs. others 0.30 (0.16–0.57) < 0.001 0.26 (0.10–0.64) 0.004
High p16INK4a/low pRB vs. others 0.32 (0.18–0.45) < 0.001 0.25 (0.11–0.60) 0.002
High p16INK4a/low pRB/low cyclin D1/low p53 vs. others 0.36 (0.19–0.38) 0.001 0.25 (0.09–0.65) 0.005
  1. Abbreviations: HR hazard ratio for death, CI confidence interval; P < 0.05 was considered statistically significant