| |
5-year overall survival
|
5-year disease-specific survival
|
|---|
|
Parameter
|
HR (95% CI)
|
p value
|
HR (95% CI)
|
p value
|
|---|
|
HR-HPV DNA (Positive vs. negative)
|
0.46 (0.26–0.81)
|
0.007
|
0.41 (0.18–0.90)
|
0.027
|
|
p16INK4a (High vs. low)
|
0.23 (0.16–0.57)
|
< 0.001
|
0.22 (0.09–0.52)
|
0.001
|
|
pRB (High vs. low)
|
2.54 (1.46–4.41)
|
0.001
|
3.20 (1.46–6.99)
|
0.004
|
|
Cyclin D1 (High vs. low)
|
1.59 (0–2.55)
|
0.053
|
1.55 (0.82–2.94)
|
0.18
|
|
p53 (High vs. low)
|
1.79 (1.12–2.86)
|
0.015
|
1.52 (0.80–2.87)
|
0.20
|
|
High p16INK4a/HR-HPV DNA positive vs. others
|
0.30 (0.16–0.57)
|
< 0.001
|
0.26 (0.10–0.64)
|
0.004
|
|
High p16INK4a/low pRB vs. others
|
0.32 (0.18–0.45)
|
< 0.001
|
0.25 (0.11–0.60)
|
0.002
|
|
High p16INK4a/low pRB/low cyclin D1/low p53 vs. others
|
0.36 (0.19–0.38)
|
0.001
|
0.25 (0.09–0.65)
|
0.005
|
- Abbreviations: HR hazard ratio for death, CI confidence interval; P < 0.05 was considered statistically significant
