Table 4 Multivariate analysis of overall and disease-specific survival for patients with OPSCC patients treated with resection

HR-HPV DNA (Positive vs. negative)

0.46 (0.26–0.81)

0.007

0.41 (0.18–0.90)

0.027

p16^INK4a (High vs. low)

0.23 (0.16–0.57)

< 0.001

0.22 (0.09–0.52)

0.001

pRB (High vs. low)

2.54 (1.46–4.41)

0.001

3.20 (1.46–6.99)

0.004

Cyclin D1 (High vs. low)

1.59 (0–2.55)

0.053

1.55 (0.82–2.94)

0.18

p53 (High vs. low)

1.79 (1.12–2.86)

0.015

1.52 (0.80–2.87)

0.20

High p16^INK4a/HR-HPV DNA positive vs. others

0.30 (0.16–0.57)

< 0.001

0.26 (0.10–0.64)

0.004

High p16^INK4a/low pRB vs. others

0.32 (0.18–0.45)

< 0.001

0.25 (0.11–0.60)

0.002

High p16^INK4a/low pRB/low cyclin D1/low p53 vs. others

0.36 (0.19–0.38)

0.001

0.25 (0.09–0.65)

0.005