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Table 1 Comparison of clinicopathological characteristics between patients with or without DLN metastasis

From: Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis

Characteristics DLN-positive (n = 19) DLN-negative (n = 173) P value
Female %(n) 42.1 (8) 72.3 (125) 0.007
Age ≥ 45 years %(n) 31.6 (6) 56.1 (97) 0.042
Tumor size ≥ 1 cm %(n) 73.7 (14) 28.3 (49) < 0.001
Tumor distribution    0.152
 left side %(n) 21.1 (4) 32.4 (56)  
 right side %(n) 42.1 (8) 50.3 (87)  
 double side %(n) 36.8 (7) 17.3 (30)  
Tumor location    0.443
 isthmus/upper third %(n) 31.6 (6) 28.9 (50)  
 middle third %(n) 26.3 (5) 40.5 (70)  
 lower third %(n) 42.1 (8) 30.6 (53)  
Multifocality %(n) 68.4 (13) 32.9 (57) 0.002
Bilaterality %(n) 36.8 (7) 17.3 (30) 0.061
ETE %(n) 42.1 (8) 5.2 (9) < 0.001
BRAFV600E mutation %(n) 31.6 (6) 21.4 (37) 0.383
Hashimoto’s thyroiditis %(n) 52.6 (10) 33.5 (58) 0.098
Tg level (ng/ml) 24.32 ± 28.70 24.22 ± 35.22 0.991
Tg-Ab level (IU/ml) 95.56 ± 164.79 83.66 ± 167.50 0.769
TPO level (IU/L) 45.29 ± 58.74 43.53 ± 93.32 0.936
TSH level (mIU/L) 2.69 ± 1.50 2.90 ± 1.65 0.590
CLNM %(n) 89.4 (17) 32.4 (56) < 0.001
Lymph nodes dissected (n) 5.32 ± 2.34 4.62 ± 2.94 0.320
Metastatic lymph nodes (n) 3.42 ± 1.84 0.84 ± 1.78 < 0.001
LLNM %(n) 26.3 (5) 4.6 (8) 0.004
Mean no. of LLNM (n) 1.16 ± 2.34 0.21 ± 1.11 0.099
  1. DLN Delphian lymph node, ETE Extrathyroid extension, Tg Thyroglobulin, Tg-Ab Thyroglobulin antibody, TPO Thyroid peroxidase, TSH Thyroid stimulating hormone, CLNM Central lymph node metastasis, LLNM Lateral lymph node metastasis