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Table 2 Defined grades of evidence and recommendations [AAP ref]

From: Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma

GradeResearchPreponderance of benefit over harmBalance of benefit and harm
AWell designed RCTs or diagnostic studiesStrong recommendationOption
BRCT or diagnostic studies with minor limitations; overwhelming consistent evidence from observational studiesStrong recommendation / recommendationOption
CObservation studies (case control and cohort design)RecommendationOption
DExpert opinion; case reports; reasoning from first principlesOptionNo recommendation