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Table 7 MRI in surveillance of IP malignant transformation summary

From: Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma

Study authorsYearStudy designLevel of evidenceStudy groupInterventionOutcomeConclusion
Yan et al. [30]2018Diagnostic studyB76 IP patients, 66 IP-SCC patientsMRI results were compared with surgical pathology reports.IP have higher prevalence of CCP on MRI, and higher ADC values.Evaluation of CCP and ADC values on MRI can help differentiate benign IP from IPSCC.
Oikawa et al. [31]2010Diagnostic studyB21 IP patientsPatient were staged based on MRI findings and the results were compared with pathological findings..The positive predictive value of MRI staging, as verified by surgical and pathological findings, was 68 to 89%.MRI can be used to accurately predict the extent of tumor involvement and staging.
Jeon et al. [32]2008Observational studyC30 IP pts., 8 with SCC, vs 128 patients with various other malignant sinonasal tumorsMR images of two groups of patients were reviewed.CCP was found in all IPs and some of the malignant sinonasal tumors. Of patients who had IP with coexistent SCC, 4 had focal loss.The sensitivity and specificity of using CCP to differentiate IP from other malignant tumors are 100 and 87%, respectively. CCP pattern cannot be used to discriminate IP from IP with SCC.
Maroldi et al. [33]2003Observational studyC23 IP patients vs. 23 malignant tumor (9 SCC)MR images of IP and malignant patients are reviewed and compared.CCP are found in all IP cases by SE T1 images, and in only 1 of MTs.A columnar pattern (CCP) is a reliable MRI indicator of IP, and reflects its histological architecture, CCP and bone erosion status can distinguish IP from malignancies.
Wang et al. [34]2014Observational studyC43 IP vs. 45 malignant tumor in nasal cavity (7 SCC)MR images of IP and malignant patients are reviewed and compared.There were significant differences between IP and malignant tumors. Washout-type TIC had a higher sensitivity and specificity in diagnosis of malignant tumors in the nasal cavity.Non-enhanced and static MRI combined with dynamic contrast enhanced MRI (DCE-MRI) could improve differentiation between IP and malignant tumors.