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Table 2 Patient and tumor characteristics of eligible studies

From: Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis

AuthorSampleAgeMaleTreatmentType of Neck DissectionT stageN stageSubsiteLNYPN+
Ye [22]93Mean 56.9 (32 to 87)98%Surgery OR Surgery with (RT OR CRT)Radical, ElectiveT1 to T4N0, N1, N2a/b/c, N3Pyriform sinus, Posterior wall, Postcricoid region,NAMean 3 (0 to 34)
Lo [15]120Mean 56 (35 to 89)98%Surgery OR Surgery with (RT OR CRT)Bilateral, UnilateralT1 to T4N0, N1, N2a/b/c, N3Pyriform sinus, Posterior pharyngeal wall, PostcricoidNAMean 4
Suzuki [21]46Median 6694%Surgery OR Surgery with (RT OR CT OR CRT)Extended radical, Modified Radical, SelectiveT1 to T4N1, N2Priform sinus, OthersMedian 59.5 (14 to 114)Median 3 (1 to 15)
Joo [14]105Mean 61 (35 to 80)97%Surgery OR Surgery with (RT OR CRT)Bilateral, Modified Radical, Radical, SelectiveT1 to T4N1 to N3Pyriform sinus, Posterior pharyngeal wall, Postcricoid regionMedian 54 (15 to 176)Median 3 (1 to 31)
Hua [13]81Median 60 (36 to 80)98%Surgery OR Surgery with (RT OR CRT)Bilateral, UnilateralT1 to T4N1 to N3Pyriform sinus, Posterior wall, Postcricoid regionMedian 47 (3 to 95)Median 2 (0 to 17)
Yu [29]279Mean 57.8 (34 to 85)93%RT OR RT with (CRT OR ICT OR Surgery OR Surgery with CT)Radical, Modified Radical, SelectiveT1 to T4N0 to N3Pyriform sinus, Posterior wall, Postcricoid regionMedian 20 (2 to 76)Median 2.0 (0.5 to 22.0)
Wang [27]916Median 61 (35 to 93)42%Surgery OR Surgery with RTNAT1 to T4a/b, TxN1 to N3Pyriform sinus, Posterior wall, Postcricoid region, Aryepiglottic fold, Overlapping lesion, HypopharynxMedian 25 (1 to 90)Median 2 (1 to 90)
Imre [19]101Mean 58.5 (41 to 79)95%Surgery OR Surgery with (RT OR CRT)Radical, Modified Radical, SelectiveT1 to T4N1, N2a/b/cGlottis, Supraglottis, TransglottisMean 41.8 (18 to 88)Mean 2.9 (1 to 15)
Ryu [16]71Median 65 (35 to 79)93%Surgery OR Surgery with (RT OR CRT)Bilateral, Modified Radical, Radical, SelectiveT1 to T4N0 to N2Supraglottis, Glottis, TransglottisMedian 52 (11 to 153),Median 4 (1 to 21)
Wang [28]1963NA78%Surgery OR
Surgery with RT
NAT1 to T4a/b, TxN1 to N3Glottis, Supraglottis, Subglottis, Laryngeal cartilage, Overlapping lesion, LarynxMedian 28 (1 to 90)Median 2 (1 to 90)
Künzel [20]202Median 59 (36 to 86)93.1%Surgery OR Surgery with (RT OR CRT)Unilateral or bilateral modified radicalT1 to T4N1, N2a/b/cGlottic,Supraglottic,Unspecified site of origin within the larynxMedian 27 (10 to 88)Median 2 (1 to 19)
Choi [12]141Median 65 (33 to 78)93.6%Surgery OR Surgery with (RT OR CRT)Radical, SelectiveT1 to T5N1 to N3Larynx, HypopharynxMedian 60 (11 to 161)Median 1 (0 to 21)
Grasl [18]79Median 60 (41.6 to 83)88.6%Surgery OR Surgery with (RT OR CRT/IRT)Radical, Modified Radical, SelectiveT1 to T4N0, N1, N2a/b/c, N3a/b/cLarynx, HypopharynxMedian ± SD
48.0 ± 23.8
NA
  1. NA Not available, RT Radiotherapy, CT Chemotherapy, CRT Chemoradiotherapy, IRT Radio-immune therapy, LNY Lymph node yield, PN+ Positive lymph node number