Skip to main content

Table 2 Patient and tumor characteristics of eligible studies

From: Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis

Author Sample Age Male Treatment Type of Neck Dissection T stage N stage Subsite LNY PN+
Ye [22] 93 Mean 56.9 (32 to 87) 98% Surgery OR Surgery with (RT OR CRT) Radical, Elective T1 to T4 N0, N1, N2a/b/c, N3 Pyriform sinus, Posterior wall, Postcricoid region, NA Mean 3 (0 to 34)
Lo [15] 120 Mean 56 (35 to 89) 98% Surgery OR Surgery with (RT OR CRT) Bilateral, Unilateral T1 to T4 N0, N1, N2a/b/c, N3 Pyriform sinus, Posterior pharyngeal wall, Postcricoid NA Mean 4
Suzuki [21] 46 Median 66 94% Surgery OR Surgery with (RT OR CT OR CRT) Extended radical, Modified Radical, Selective T1 to T4 N1, N2 Priform sinus, Others Median 59.5 (14 to 114) Median 3 (1 to 15)
Joo [14] 105 Mean 61 (35 to 80) 97% Surgery OR Surgery with (RT OR CRT) Bilateral, Modified Radical, Radical, Selective T1 to T4 N1 to N3 Pyriform sinus, Posterior pharyngeal wall, Postcricoid region Median 54 (15 to 176) Median 3 (1 to 31)
Hua [13] 81 Median 60 (36 to 80) 98% Surgery OR Surgery with (RT OR CRT) Bilateral, Unilateral T1 to T4 N1 to N3 Pyriform sinus, Posterior wall, Postcricoid region Median 47 (3 to 95) Median 2 (0 to 17)
Yu [29] 279 Mean 57.8 (34 to 85) 93% RT OR RT with (CRT OR ICT OR Surgery OR Surgery with CT) Radical, Modified Radical, Selective T1 to T4 N0 to N3 Pyriform sinus, Posterior wall, Postcricoid region Median 20 (2 to 76) Median 2.0 (0.5 to 22.0)
Wang [27] 916 Median 61 (35 to 93) 42% Surgery OR Surgery with RT NA T1 to T4a/b, Tx N1 to N3 Pyriform sinus, Posterior wall, Postcricoid region, Aryepiglottic fold, Overlapping lesion, Hypopharynx Median 25 (1 to 90) Median 2 (1 to 90)
Imre [19] 101 Mean 58.5 (41 to 79) 95% Surgery OR Surgery with (RT OR CRT) Radical, Modified Radical, Selective T1 to T4 N1, N2a/b/c Glottis, Supraglottis, Transglottis Mean 41.8 (18 to 88) Mean 2.9 (1 to 15)
Ryu [16] 71 Median 65 (35 to 79) 93% Surgery OR Surgery with (RT OR CRT) Bilateral, Modified Radical, Radical, Selective T1 to T4 N0 to N2 Supraglottis, Glottis, Transglottis Median 52 (11 to 153), Median 4 (1 to 21)
Wang [28] 1963 NA 78% Surgery OR
Surgery with RT
NA T1 to T4a/b, Tx N1 to N3 Glottis, Supraglottis, Subglottis, Laryngeal cartilage, Overlapping lesion, Larynx Median 28 (1 to 90) Median 2 (1 to 90)
Künzel [20] 202 Median 59 (36 to 86) 93.1% Surgery OR Surgery with (RT OR CRT) Unilateral or bilateral modified radical T1 to T4 N1, N2a/b/c Glottic,Supraglottic,Unspecified site of origin within the larynx Median 27 (10 to 88) Median 2 (1 to 19)
Choi [12] 141 Median 65 (33 to 78) 93.6% Surgery OR Surgery with (RT OR CRT) Radical, Selective T1 to T5 N1 to N3 Larynx, Hypopharynx Median 60 (11 to 161) Median 1 (0 to 21)
Grasl [18] 79 Median 60 (41.6 to 83) 88.6% Surgery OR Surgery with (RT OR CRT/IRT) Radical, Modified Radical, Selective T1 to T4 N0, N1, N2a/b/c, N3a/b/c Larynx, Hypopharynx Median ± SD
48.0 ± 23.8
NA
  1. NA Not available, RT Radiotherapy, CT Chemotherapy, CRT Chemoradiotherapy, IRT Radio-immune therapy, LNY Lymph node yield, PN+ Positive lymph node number