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Table 2 Quantifiable metrics of acute exacerbations in CRS

From: Definition and characteristics of acute exacerbation in adult patients with chronic rhinosinusitis: a systematic review

Author/year Evaluation parameters of AE Results Conclusions Level of evidence
Phillips, et al. (2017) [6] Number of CRS-related antibiotics usage, sinus infections SNOT-22 score is associated with the number of antibiotics; Antibiotic usage highly correlated with the number of reported sinus infections. Sinusitis-related antibiotic usage, reflecting the frequency of acute CRS exacerbations, mediates the association between CRS symptomatology and QOL. 3a
Banoub, et al. (2018) [11] Number of sinus infections, CRS-related antibiotics use, CRS-related oral corticosteroids use The frequency of patient-reported sinus infections, CRS-related antibiotics courses and CRS-related oral corticosteroid courses was negatively associated with asthma control. AE are negatively associated with the level of asthma control. 3a
Phillips, et al. (2019) [18] Number of sinus infections, CRS-related antibiotics, CRS-related oral corticosteroids AE positively associated with comorbid asthma, and SNOT-22. A CRS exacerbation-prone phenotype characterized by high sinonasal disease burden with comorbid asthma. 3a
Sedaghat, et al. (2018) [19] Number of sinus infections, CRS-related oral antibiotic, CRS-related oral corticosteroids At least 1 course of antibiotics or oral corticosteroids in the last 3 months was the optimal threshold for detecting poorly controlled CRS. Number of CRS-related antibiotic use, and CRS-related oral corticosteroid aid in the determination of global CRS control. 3a
Speth, et al. (2018) [20] Number of sinus infections, CRS-related antibiotics, CRS-related steroid usage SNOT-22 score ≥ 30 predicted at least 1 sinus infection, CRS-related antibiotics, or CRS-related oral corticosteroids in the past 3 months. SNOT-22 score and AE were predictive of each other. 3a
Zemke, et al. (2019) [13] SNOT-22 scores SNOT-22 scores were 4.9 points higher during the AE Changes of SNOT-22 indicate the AE. 3a
Diveka, et al. (2015) [14] SNOT-22 scores SNOT-22 scores were 10.75 higher during the AE Changes of SNOT-22 indicate the AE. 3a
  1. CRS Chronic rhinosinusitis, AE Acute exacerbation, QOL Quality of life, SNOT-22 The 22-item Sino- Nasal Outcome Test