Fig. 4

No significant differences in rate of general, mental and asthmatic health burden are seen between ^InitialTPS ≤ 4 and ^InitialTPS ≥ 5 groups. Spaghetti plots produced through statistical modelling display rate of change across time (0–6 months, x-axes) in PHQ-2 (y-axis = score 0–6) (a), EQ5D-3L (y-axis = score 0–15) (b), ACT (y-axis = score 0–25) (c) and Mini-AQLQ scores (y-axis = score 0–7) (d). Black lines represent individual patients and green lines indicate the estimated rate of change according to the statistical model