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Table 4 Bias analysis

From: Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review

References

Tobacco

Alcohol

HPV

Como

Stage

Surgery

RT

Onco

Burns et al. [12]

No

No

No

Probably yes

Yes

Yes

Yes

Yes

Ferlito and Recher [26]

No

No

No

Probably yes

Probably yes

Yes

Probably no

Probably yes

Blakeslee et al. [14]

No

No

No

Probably no

Yes

Yes

Yes

Lundgren et al. [8]

No

No

No

Probably yes

Yes

Yes

Yes

Yes

Sllamniky et al. [15]

No

No

No

No

Yes

Probably yes

Yes

Hagen et al. [16]

Probably yes

No

No

No

Yes

Yes

Probably yes

Probably yes

Fliss et al. [17]

No

No

Yes

No

Yes

Yes

Yes

Yes

Longarela Herrero et al. [18]

No

No

No

No

Probably no

Yes

Yes

Maurizi et al. [19]

Probably no

No

No

No

Yes

Yes

No

Probably yes

Damm et al. [20]

Probably yes

No

No

Probably no

Yes

Yes

Yes

McCaffrey et al. [21]

No

No

No

No

Yes

Probably no

Probably yes

Probably yes

Strojan et al. [22]

No

No

No

No

Yes

Probably yes

Yes

Probably yes

Hod et al. [23]

Probably no

Probably no

No

No

Yes

Probably yes

No

Yes

Huang et al. [24]

Probably yes

No

No

No

Yes

Yes

Yes

Dubal et al. [3]

No

No

No

No

Yes

Probably yes

No

Yes

Jayakrishnan et al. [25]

No

No

No

Probably no

Probably yes

Probably yes

No

Yes

  1. According to the bias tool used, the following points were considered: Tobacco/alcohol/HPV: yes = authors provided full details of tobacco or alcohol overuse or HPV infection; probably yes = authors provided partial details of all patients; probably no = authors provided partial details of some patients; no = no detail found. Comorbidities (como): yes = authors provided full comorbidity details of patient cohort; probably yes = authors provided selected comorbidity details of patients for the oncological outcome analysis; probably no = authors provided few details for few patients; no = no detail provided. Stage: yes = cTNM stages and anatomical locations of all tumors were provided; probably yes = authors provided incomplete cTNM stages or anatomical features of cohort; probably no = only cTNM or anatomical location were available for some patients; no cTNM/anatomical location details were provided. Surgery: yes = details of surgical treatments were reported (types of surgery for primary tumor AND neck dissection features); probably yes = some details of surgical treatment were provided for all patients (types of surgery OR neck dissection features); probably no = authors did not report the types of surgery or neck dissection features for all patients; no = no detail provided about the surgery or dissection features for any patient. Radiotherapy (RT): yes = full details of radiation treatment were provided for all patients (number of session AND doses AND type of RT); probably yes = partial details were found for all patients (number of session OR doses OR type of RT); probably no = partial details were provided for some patients (number of session OR doses OR type of RT); no = no detail of RT treatment. Oncological outcomes (onco): yes = oncological outcomes were reported for entire cohort and according to treatment; probably yes = oncological outcomes were provided for entire cohort without treatment detail; probably no = oncological outcomes were provided for some patients without treatment details; no = oncological outcomes were not reported