Table 6 Literature studies
From: Variability and accuracy of multiple saliva pepsin measurements in laryngopharyngeal reflux patients
Authors | Ref | Years | LPR/CT | LPR diagnosis | Sample time | Pepsin analysis | Thresholds | SE | SP | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Wang | 10 | 2022 | 112/26 | HEMII-pH | From morning | Rapid pepsin | > 45 ng/mL | 38.4 | 84.6 | 91.5 | 24.2 | 55.7 |
China | ≥ 1 HRE | 07:00:00 to | lateral flow | Fasting test | ||||||||
6:00 PM | Highest saliva | > 45 ng/mL | 86.6 | 80.8 | 95.1 | 58.3 | 73.9 | |||||
concentration | Highest test | |||||||||||
Zelenik | 9 | 2021 | 45/1 | HEMII-pH | Morning | PepTest® | ≥ 16 ng/mL | 48.0 | 27.0 | 63.0 | 40.0 | 48.0 |
Czech | > 1 HRE | |||||||||||
Zhang | 7 | 2020 | 26/4 | HEMII-pH | Morning | PepTest® | ≥ 16 ng/mL | 76.9 | 25.0 | 87.0 | 14.3 | 87.0 |
Australia | ≥ 2 HRE | 1-h post-lunch | ≥ 75 ng/mL | 57.7 | 75.0 | 93.8 | 21.4 | N.P | ||||
≥ 6 PRE | 1-h post-dinner | |||||||||||
When symptoms | ||||||||||||
Klimara | 2 | 2019 | 19/7 | HEMII-pH | Morning | ELISA | > 1 ng/mL | 29.4 | 50.0 | 62.5 | 20.0 | 42.0 |
U.S.A | > 1 HRE | 1-h post-lunch | Western blot | |||||||||
> 40 PRE | 1-h post-dinner | Higesth pepsin | ||||||||||
1-h post-breakfast | concentration | |||||||||||
Weitzendorfer | 15 | 2019 | 41/29 | Restech | 3 samples | PepTest® | > 16 ng/mL | 85.4 | 27.6 | 62.5 | 57.1 | 85.4 |
Austria | Ryan score | Highest of | > 50 ng/mL | 78.1 | 41.4 | 65.3 | 57.1 | |||||
(> 9.4) | 3 samples | > 100 ng/mL | 68.3 | 58.6 | 70.0 | 56.7 | ||||||
> 150 ng/mL | 53.7 | 69.0 | 71.0 | 51.3 | ||||||||
> 216 ng/mL | 41.5 | 86.2 | 81.0 | 51.0 | ||||||||
Hayat | 6 | 2015 | 111/100 | MII-pH | Morning | PepTest® | > 16 ng/mL | 77.6 | 63.2 | 58.4 | 80.4 | N.P |
U.K | EAT > 4.2% | 1-h post-lunch | > 50 ng/mL | 67.2 | 76.3 | 67.2 | 76.8 | |||||
1-h post-dinner | > 100 ng/mL | 51.7 | 74.5 | 54.5 | 72.3 | |||||||
> 150 ng/mL | 41.4 | 90.8 | 75.0 | 69.9 | ||||||||
> 210 ng/mL | 44.2 | 96.3 | 95.7 | 36.5 | ||||||||
Ocak | 16 | 2015 | 18/2 | Dual-probe | N.P | PepTest® | ≥ 16 ng/mL | 33.0 | 100 | 100 | 14.2 | N.P |
Turkey | pH testing | |||||||||||
EAT > 4.2% | ||||||||||||
Saritas | 17 | 2012 | 22/25 | Wireless | N.P | PepTest® | ≥ 50 ng/mL | 50.0 | 92.0 | 85.0 | 68.0 | N.P |
U.S.A | pH testing | |||||||||||
EAT > 4.2% | ||||||||||||
Potluri | 18 | 2003 | 3/13 | Dual-probe pH testing | When symptoms | Pepsin assay | > 1 ng/mL | 100 | 92.3 | N.P | N.P | N.P |
U.S.A | ≥ 1 proximal acid | |||||||||||
esophageal event |