Table 1 Patient characteristics
Characteristic | TMPRSS3-Group, N = 33 ears (100%) | Control-group, N = 67 ears (100%) | P value |
|---|---|---|---|
Gender, % female | 15 (45.5) | 43 (64.2) | 0.074 |
Age at implantation (mean ± SD) | 24 ± 19 | 27 ± 26 | 0.584 |
Duration of hearing loss prior to implantation (mean ± SD) | 16 ± 14 | 17 ± 18 | 0.908 |
Learning difficulties | 1 (3.0) | Â | 0.165 |
EVA on CT or MRI | 0 (0.0) | 15 (22.4) | 0.045 |
Affected gene | |||
 ACTB | 0 (0.0) (0 (0.0).0 (0.0)) | 1 (1.5) |  |
 ACTG1 | 0 (0.0) (0 (0.0).0 (0.0)) | 1 (1.5) |  |
 ADGRV1 | 0 (0.0) | 1 (1.5) |  |
 CEP95 | 0 (0.0) | 1 (1.5) |  |
 CLRN1 | 0 (0.0) | 3 (4.5) |  |
 COCH | 0 (0.0) | 10 (14.9) |  |
 GJB2 | 0 (0.0) | 8 (11.9) |  |
 GJB6 | 0 (0.0) | 1 (1.5) |  |
 LARS2 | 0 (0.0) | 1 (1.5) |  |
 MITF | 0 (0.0) | 2 (3.0) |  |
 MITO | 0 (0.0) | 1 (1.5) |  |
 MYO15A | 0 (0.0) | 5(7.5) |  |
 MYO7A | 0 (0.0) | 4 (6.0) |  |
 POU4F3 | 0 (0.0) | 1 (1.5) |  |
 PRPS1 | 0 (0.0) | 1 (1.5) |  |
 PTPN11 | 0 (0.0) | 1 (1.5) |  |
 SLC26A4 | 0 (0.0) | 15 (22.4) |  |
 SOX10 | 0 (0.0) | 1 (1.5) |  |
 TMPRSS3 | 33 (100) | 0(0.0) |  |
 TPRN | 0 (0.0) | 2 (3.0) |  |
 TUBB4B | 0 (0.0) | 2 (2.5) |  |
 USH2A | 0 (0.0) | 3 (4.5) |  |
 WFS1 | 0 (0.0) | 2 (3.0) |  |
CI side | |||
 Left | 15 (45.5) | 30 (44.8) | 0.173 |
 Right | 14 (42.4) | 35(52.2) |  |
 Bilateral (simultaneously) | 4 (21.1) | 2 (3.0) |  |
Hearing aid in ear to be implanted | 21 (63.6) | 46 (68.7) | 0.616 |
Surgical technique | |||
 Cochleostomy | 15 (45.5) | 54 (80.6) | 0.002 |
 Round window | 16 (48.5) | 13 (19.4) |  |
 Extended round window | 1 (3.0) | 0 (0.0) |  |
 Not reported | 1 (3.0) | 0 (0.0) |  |