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  1. Review

    Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review

    To review the available evidence and make recommendations regarding use of systemically administered drugs in combination or in sequence with radiation (RT) and/or surgery for cure and/or organ preservation in...

    Eric Winquist, Chika Agbassi, Brandon M. Meyers, John Yoo and Kelvin K. W. Chan

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:29

    Published on: 4 April 2017

  2. Original research article

    Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

    Sudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient’s social and relational life. The underlying pathomechanisms have not been finally clarified yet and outcome is not pre...

    Daniel Weiss, Armin Julius Böcker, Mario Koopmann, Eleftherios Savvas, Matthias Borowski and Claudia Rudack

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:27

    Published on: 4 April 2017

  3. Original research article

    Can floseal™ be applied safely during otologic surgery? Assessment of ototoxicity in a chinchilla animal model

    In otologic surgery good visualization is paramount, and patients with bleeding diatheses or who need to be anti-coagulated can present a significant challenge. Here, we determine whether Floseal™, a hemostati...

    Carol Nhan, Aren Bezdjian, Abdullah Alarfaj and Sam J. Daniel

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:24

    Published on: 29 March 2017

  4. Original research article

    Incidence and burden of comorbid pain and depression in patients with chronic rhinosinusitis awaiting endoscopic sinus surgery in Canada

    This study sheds important light on the association between sino-nasal symptoms and global quality of life in patients with chronic rhinosinusitis waiting for endoscopic sinus surgery. Using patient-reported i...

    Bassem M. N. Hanna, R. Trafford Crump, Guiping Liu, Jason M. Sutherland and Arif S. Janjua

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:23

    Published on: 27 March 2017

  5. Original research article

    Thyroid incidentalomas on 18FDG-PET/CT: a metabolico-pathological correlation

    Thyroid incidentaloma is defined as an unsuspected thyroid lesion found on imaging study or while performing a surgery non-related to the thyroid gland. Most recent scientific literature tends to demonstrate a...

    N. Hagenimana, J. Dallaire, É. Vallée and M. Belzile

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:22

    Published on: 21 March 2017

  6. Short report

    Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients

    FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infectio...

    Tack-Kyun Kwon, Eun Jae Chung, Nuri Lee, Eun Youn Roh and Eun Young Song

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:21

    Published on: 15 March 2017

  7. Original research article

    Transoral robotic surgery with radial forearm free flap reconstruction: case control analysis

    The resection of large oropharyngeal tumors traditionally involves a lip-splitting mandibulotomy for adequate margin visualization and free flap reconstruction of the surgical defect. Transoral robotic surgery...

    Vincent L. Biron, Daniel A. O’Connell, Brittany Barber, Jessica M. Clark, Colin Andrews, Caroline C. Jeffery, David W. J. Côté, Jeffrey Harris and Hadi Seikaly

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:20

    Published on: 14 March 2017

  8. Review

    Measuring Cochlear Duct Length – a historical analysis of methods and results

    Cochlear Duct Length (CDL) has been an important measure for the development and advancement of cochlear implants. Emerging literature has shown CDL can be used in preoperative settings to select the proper si...

    Robert W. Koch, Hanif M. Ladak, Mai Elfarnawany and Sumit K. Agrawal

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:19

    Published on: 7 March 2017

  9. Original research article

    Mobile tablet audiometry in fluctuating autoimmune ear disease

    Autoimmune inner ear disease (AIED) is a rare condition characterized by bilateral fluctuating sensorineural hearing loss (SNHL). The labile nature of this hearing loss makes it difficult to accurately quantif...

    Scott Kohlert and Matthew Bromwich

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:18

    Published on: 7 March 2017

  10. Case report

    Tumor-to-tumor metastases: papillary thyroid carcinoma into a clear cell renal cell carcinoma

    Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8–3.8% for papillary and 6–20...

    Jin Soo Andy Song, S. Mark Taylor, Jonathan Trites, Matthew H. Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon and Robert D. Hart

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:17

    Published on: 1 March 2017

  11. Original research article

    Securing an OTL-HNS residency: how competitive is it? Comparing medical student perceptions to actual Canadian statistics

    The residency match is an important event in an aspiring physician’s career. Otolaryngology – Head and Neck Surgery (OTL-HNS) is a surgical specialty that has enjoyed high numbers of applicants to its residenc...

    E. Kay-Rivest, N. Varma, G. M. Scott, J. J. Manoukian, M. Desrosiers, J. P. Vaccani and L. H. P. Nguyen

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:16

    Published on: 27 February 2017

  12. Original research article

    The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma

    HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. ...

    Faisal Alzahrani, Leanne Clattenburg, Shanmugam Muruganandan, Martin Bullock, Kaitlyn MacIsaac, Michael Wigerius, Blair A. Williams, M. Elise R. Graham, Matthew H. Rigby, Jonathan R. B. Trites, S. Mark Taylor, Christopher J. Sinal, James P. Fawcett and Robert D. Hart

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:15

    Published on: 22 February 2017

  13. Original research article

    Medialization thyroplasty versus injection laryngoplasty: a cost minimization analysis

    Medialization thyroplasty and injection laryngoplasty are widely accepted treatment options for unilateral vocal fold paralysis. Although both procedures result in similar clinical outcomes, little is known ab...

    Samantha Tam, Hongmei Sun, Sisira Sarma, Jennifer Siu, Kevin Fung and Leigh Sowerby

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:14

    Published on: 20 February 2017

  14. Original research article

    Does drug-induced sleep endoscopy change the surgical decision in surgically naïve non-syndromic children with snoring/sleep disordered breathing from the standard adenotonsillectomy? A retrospective cohort study

    Adenotonsillectomy is the most commonly performed operation for pediatric snoring/sleep disordered breathing (S/SDB). However, 20–40% of patients will fail to improve. Drug-induced sleep endoscopy (DISE) may p...

    Malak Jamal Gazzaz, André Isaac, Scott Anderson, Noura Alsufyani, Yaser Alrajhi and Hamdy El-Hakim

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:12

    Published on: 13 February 2017

  15. Original research article

    Developing a new diagnostic algorithm for human papilloma virus associated oropharyngeal carcinoma: an investigation of HPV DNA assays

    Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopatholog...

    Natasha Cohen, Michael Gupta, Lilian Doerwald-Munoz, Dan Jang, James Edward Massey Young, Stuart Archibald, Bernard Jackson, Jenny Lee and Max Chernesky

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:11

    Published on: 13 February 2017

  16. Original research article

    Formal mentorship in a surgical residency training program: a prospective interventional study

    Otolaryngology-Head and Neck surgery resident physicians (OHNSR) have a high prevalence of burnout, job dissatisfaction and stress as shown within the literature. Formal mentorship programs (FMP) have a proven...

    Han Zhang, Andre Isaac, Erin D. Wright, Yaser Alrajhi and Hadi Seikaly

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:13

    Published on: 13 February 2017

  17. Original research article

    Three-dimensional morphological changes of the temporomandibular joint and functional effects after mandibulotomy

    The midline and paramedian mandibulotomy are surgical procedures that divide the mandibular bone into two halves and disconnects the condylar heads of the TMJ from each other. This study aimed to prospectively...

    Mohammed A. Q. Al-Saleh, Kumaradevan Punithakumar, Manuel Lagravere, Pierre Boulanger, Jacob L. Jaremko, John Wolfaardt, Paul W. Major and Hadi Seikaly

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:8

    Published on: 28 January 2017

  18. Original research article

    Vascular mapping of the retroauricular skin – proposal for a posterior superior surgical incision for transcutaneous bone-conduction hearing implants

    Passive transcutaneous osseointegrated hearing implant systems have become increasingly popular more recently. The area over the implant is vulnerable due to vibration and pressure from the externally worn sou...

    Adam Perenyi, Zsofia Bere, Janos Jarabin, Balazs Sztano, Edit Kukla, Ziad Bikhazi, Laszlo Tiszlavicz, Ferenc Toth, Jozsef Geza Kiss and Laszlo Rovo

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:6

    Published on: 17 January 2017

  19. Original research article

    Differences in RANTES and IL-6 levels among chronic rhinosinusitis patients with predominant gram-negative and gram-positive infection

    Bacteria are suspected players in the pathogenesis of chronic rhinosinusitis (CRS), yet their exact role is not understood. We investigated the effect of planktonic and biofilm of staphylococcus aureus (SA) an...

    Almoaidbellah Rammal, Marc Tewfik and Simon Rousseau

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:7

    Published on: 17 January 2017

  20. Original research article

    Ultrasensitive detection of oncogenic human papillomavirus in oropharyngeal tissue swabs

    The incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by oncogenic human papillomavirus (HPV) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV E6 and E7 oncoproteins or by...

    Andre Isaac, Morris Kostiuk, Han Zhang, Cameron Lindsay, Fawaz Makki, Daniel A. O’Connell, Jeffrey R. Harris, David W. J. Cote, Hadi Seikaly and Vincent L. Biron

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:5

    Published on: 14 January 2017

  21. Case report

    The dangers of parathyroid biopsy

    We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement.

    Joanne Kim, Gilad Horowitz, Michael Hong, Mario Orsini, Sylvia L. Asa and Kevin Higgins

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:4

    Published on: 7 January 2017

  22. Original research article

    HPV DNA in saliva from patients with SCC of the head and neck is specific for p16-positive oropharyngeal tumours

    Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection o...

    Jason K. Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten and Stephanie Johnson-Obaseki

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:3

    Published on: 6 January 2017

  23. Original research article

    Audiometric findings with voluntary tensor tympani contraction

    Tensor tympani contraction may have a "signature" audiogram. This study demonstrates audiometric findings during voluntary tensor tympani contraction.

    Brandon Wickens, Duncan Floyd and Manohar Bance

    Journal of Otolaryngology - Head & Neck Surgery 2017 46:2

    Published on: 5 January 2017

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