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  1. Content type: Short report

    FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infectio...

    Authors: Tack-Kyun Kwon, Eun Jae Chung, Nuri Lee, Eun Youn Roh and Eun Young Song

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:21

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  2. Content type: Original research article

    The resection of large oropharyngeal tumors traditionally involves a lip-splitting mandibulotomy for adequate margin visualization and free flap reconstruction of the surgical defect. Transoral robotic surgery...

    Authors: Vincent L. Biron, Daniel A. O’Connell, Brittany Barber, Jessica M. Clark, Colin Andrews, Caroline C. Jeffery, David W. J. Côté, Jeffrey Harris and Hadi Seikaly

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:20

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  3. Content type: Review

    Cochlear Duct Length (CDL) has been an important measure for the development and advancement of cochlear implants. Emerging literature has shown CDL can be used in preoperative settings to select the proper si...

    Authors: Robert W. Koch, Hanif M. Ladak, Mai Elfarnawany and Sumit K. Agrawal

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:19

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  4. Content type: Original research article

    Autoimmune inner ear disease (AIED) is a rare condition characterized by bilateral fluctuating sensorineural hearing loss (SNHL). The labile nature of this hearing loss makes it difficult to accurately quantif...

    Authors: Scott Kohlert and Matthew Bromwich

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:18

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  5. Content type: Case report

    Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8–3.8% for papillary and 6–20...

    Authors: Jin Soo Andy Song, S. Mark Taylor, Jonathan Trites, Matthew H. Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon and Robert D. Hart

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:17

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  6. Content type: Original research article

    The residency match is an important event in an aspiring physician’s career. Otolaryngology – Head and Neck Surgery (OTL-HNS) is a surgical specialty that has enjoyed high numbers of applicants to its residenc...

    Authors: E. Kay-Rivest, N. Varma, G. M. Scott, J. J. Manoukian, M. Desrosiers, J. P. Vaccani and L. H. P. Nguyen

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:16

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  7. Content type: Original research article

    HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. ...

    Authors: Faisal Alzahrani, Leanne Clattenburg, Shanmugam Muruganandan, Martin Bullock, Kaitlyn MacIsaac, Michael Wigerius, Blair A. Williams, M. Elise R. Graham, Matthew H. Rigby, Jonathan R. B. Trites, S. Mark Taylor, Christopher J. Sinal, James P. Fawcett and Robert D. Hart

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:15

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  8. Content type: Original research article

    Medialization thyroplasty and injection laryngoplasty are widely accepted treatment options for unilateral vocal fold paralysis. Although both procedures result in similar clinical outcomes, little is known ab...

    Authors: Samantha Tam, Hongmei Sun, Sisira Sarma, Jennifer Siu, Kevin Fung and Leigh Sowerby

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:14

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  9. Content type: Original research article

    Otolaryngology-Head and Neck surgery resident physicians (OHNSR) have a high prevalence of burnout, job dissatisfaction and stress as shown within the literature. Formal mentorship programs (FMP) have a proven...

    Authors: Han Zhang, Andre Isaac, Erin D. Wright, Yaser Alrajhi and Hadi Seikaly

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:13

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  10. Content type: Original research article

    Adenotonsillectomy is the most commonly performed operation for pediatric snoring/sleep disordered breathing (S/SDB). However, 20–40% of patients will fail to improve. Drug-induced sleep endoscopy (DISE) may p...

    Authors: Malak Jamal Gazzaz, André Isaac, Scott Anderson, Noura Alsufyani, Yaser Alrajhi and Hamdy El-Hakim

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:12

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  11. Content type: Original research article

    Human papilloma virus (HPV) has been implicated in the development of a large proportion of oropharyngeal squamous cell carcinoma (OPSCC). Current techniques used to diagnose HPV etiology require histopatholog...

    Authors: Natasha Cohen, Michael Gupta, Lilian Doerwald-Munoz, Dan Jang, James Edward Massey Young, Stuart Archibald, Bernard Jackson, Jenny Lee and Max Chernesky

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:11

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  12. Content type: Original research article

    The objective of this study was to validate our approach of treating primary hyperparathyroidism using sestamibi scan directed parathyroidectomy, without routine use of intraoperative parathyroid hormone measu...

    Authors: Alexandra Thielmann and Paul Kerr

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:10

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  13. Content type: Review

    Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-c...

    Authors: Cameron Lindsay, Hadi Seikaly and Vincent L. Biron

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:9

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  14. Content type: Original research article

    The midline and paramedian mandibulotomy are surgical procedures that divide the mandibular bone into two halves and disconnects the condylar heads of the TMJ from each other. This study aimed to prospectively...

    Authors: Mohammed A. Q. Al-Saleh, Kumaradevan Punithakumar, Manuel Lagravere, Pierre Boulanger, Jacob L. Jaremko, John Wolfaardt, Paul W. Major and Hadi Seikaly

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:8

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  15. Content type: Original research article

    Bacteria are suspected players in the pathogenesis of chronic rhinosinusitis (CRS), yet their exact role is not understood. We investigated the effect of planktonic and biofilm of staphylococcus aureus (SA) an...

    Authors: Almoaidbellah Rammal, Marc Tewfik and Simon Rousseau

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:7

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  16. Content type: Original research article

    Passive transcutaneous osseointegrated hearing implant systems have become increasingly popular more recently. The area over the implant is vulnerable due to vibration and pressure from the externally worn sou...

    Authors: Adam Perenyi, Zsofia Bere, Janos Jarabin, Balazs Sztano, Edit Kukla, Ziad Bikhazi, Laszlo Tiszlavicz, Ferenc Toth, Jozsef Geza Kiss and Laszlo Rovo

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:6

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  17. Content type: Original research article

    The incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by oncogenic human papillomavirus (HPV) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV E6 and E7 oncoproteins or by...

    Authors: Andre Isaac, Morris Kostiuk, Han Zhang, Cameron Lindsay, Fawaz Makki, Daniel A. O’Connell, Jeffrey R. Harris, David W. J. Cote, Hadi Seikaly and Vincent L. Biron

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:5

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  18. Content type: Case report

    We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement.

    Authors: Joanne Kim, Gilad Horowitz, Michael Hong, Mario Orsini, Sylvia L. Asa and Kevin Higgins

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:4

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  19. Content type: Original research article

    Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection o...

    Authors: Jason K. Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten and Stephanie Johnson-Obaseki

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:3

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    The Correction to this article has been published in Journal of Otolaryngology - Head & Neck Surgery 2018 47:49

  20. Content type: Case report

    Bell´s palsy is the most common cause of facial paralysis worldwide and the most common disorder of the cranial nerves. It is a diagnosis of exclusion, accounting for 60–75% of all acquired peripheral facial n...

    Authors: S. K. Mueller, H. Iro, M. Lell, F. Seifert, C. Bohr, C. Scherl, A. Agaimy and M. Traxdorf

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2017 46:1

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  21. Content type: Original research article

    The conventional technique for cancer resection margin analysis studies only 0.1% of the surgical margins. Complete frozen section margins - also known as Mohs margins – allows for analysis of 100% of the surg...

    Authors: Mathieu Bergeron, Pierre Gauthier and Nathalie Audet

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:63

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  22. Content type: Original research article

    The majority of chemoradiation (CRT) trials for locally advanced head and neck squamous cell carcinoma (HNSCC) have relied on platinum-based chemotherapy regimens administered every-3-weeks. However, given the...

    Authors: James M. Melotek, Benjamin T. Cooper, Matthew Koshy, Joshua S. Silverman and Michael T. Spiotto

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:62

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  23. Content type: Original research article

    Neck metastasis is the most important prognostic factor in oral cavity squamous cell carcinomas (SCC). Apart from the T- stage, depth of invasion has been used as a highly predictable factor for microscopic ne...

    Authors: H. A. Alsaffar, D. P. Goldstein, E. V. King, J. R. de Almeida, D. H. Brown, R. W. Gilbert, P J. Gullane, O. Espin-Garcia, W. Xu and J. C. Irish

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:61

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  24. Content type: Original research article

    Binostril endoscopic transsphenoidal approach (BETA) provides sufficient manipulation space and wide endoscopic vision, although it increases the trauma of nose. Mononostril endoscopic transsphenoidal approach...

    Authors: Guodao Wen, Chao Tang, Chunyu Zhong, Junyang Li, Zixiang Cong, Yuan Zhou, Kaidong Liu, Yong Zhang, Mamatemin Tohti and Chiyuan Ma

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:60

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  25. Content type: Original research article

    Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the s...

    Authors: Jérôme R. Lechien, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies and Sven Saussez

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:59

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  26. Content type: Original research article

    Long operating time and high blood loss contribute to post-surgical morbidity. Therefore, strategies to reduce these factors should to be tested using robust methods.

    Authors: Dieter K. Fritz, T. Wayne Matthews, Shamir P. Chandarana, Steven C. Nakoneshny and Joseph C. Dort

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:58

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  27. Content type: Original research article

    To describe the process involved in developing a decision aid prototype for parents considering adenotonsillectomy for their children with sleep disordered breathing.

    Authors: Erin Maguire, Paul Hong, Krista Ritchie, Jeremy Meier, Karen Archibald and Jill Chorney

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:57

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  28. Content type: Original research article

    To explore the feasibility, the efficacy, and the mechanism of mandibular advancement devices (MAD) in the treatment of persistent sleep apnea after surgery.

    Authors: Huiping Luo, Xulan Tang, Yuanping Xiong, Lili Meng, Hongliang Yi and Shankai Yin

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:56

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  29. Content type: Original research article

    Indications for performing a prophylactic central neck dissection (pCND) in papillary thyroid cancer (PTC) remain controversial. It is unclear how identification of lymph node (LN) metastases should impact the...

    Authors: Michael W. Deutschmann, Laura Chin-Lenn, Steven C. Nakoneshny, Joseph C. Dort, Janice L. Pasieka and Shamir P. Chandarana

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:55

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  30. Content type: Original research article

    In recent decades, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising worldwide as a result of increasing oncogenic human papillomavirus (HPV) infections in the oropharynx. EZH2 is ...

    Authors: Sherif Idris, Cameron Lindsay, Morris Kostiuk, Colin Andrews, David W. J. Côté, Daniel A. O’Connell, Jeffrey Harris, Hadi Seikaly and Vincent L. Biron

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:54

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  31. Content type: Case report

    Ectopic parathyroid adenomas can occur in numerous anatomic locations. While ectopic parathyroid adenomas can rarely occur in the pharyngeal region, this has not previously been described in the soft palate.

    Authors: Brent A. Chang, Anil Sharma and Donald W. Anderson

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:53

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  32. Content type: Original research article

    Management decisions are not straightforward when the Ultrasound Guided Fine Needle Aspiration (USFNA) demonstrates a Bethesda score of either category III or IV, and a diagnostic hemi-thyroidectomy or a repea...

    Authors: Alborz Jooya, Joe Saliba, Audrey Blackburn, Michael Tamilia, Michael P. Hier, Alex Mlynarek, Véronique-Isabelle Forest, Louise Rochon, Anca Florea, Hangjun Wang and Richard J. Payne

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:51

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  33. Content type: Original research article

    A commonly employed treatment for advanced staged oropharyngeal squamous cell carcinoma (OPSCC) is concurrent radiation and chemotherapy with cisplatin as the gold standard. Carboplatin is reported to have the...

    Authors: M. Roskies, E. Kay-Rivest, M. A. Mascarella, K. Sultanem, A. Mlynarek and M. Hier

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:50

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  34. Content type: Short report

    Hearing deficits in children are demonstrably negatively associated with language acquisition and cognition. Although universal neonatal hearing screening exists, it is not offered equally across Canada. Addit...

    Authors: Tina Hu, Katherine Stead, Terence Fu and Blake Papsin

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:49

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  35. Content type: Original research article

    Deformity in the dental arc and facial skeleton by adenoid hypertrophy due to chronic mouth breathing is a well-known process. Most of the related studies have been based on cephalometric analyses. The aim of ...

    Authors: Cigdem Fırat Koca, Tamer Erdem and Tuba Bayındır

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:48

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  36. Content type: Short report

    Little is known regarding the etiology and genomic underpinnings of Oral Tongue Squamous Cell Carcinoma (OTSCC) in patients who lack traditional risk factors, yet the incidence is increasing. In particular, th...

    Authors: Daniel L. Faden, Sarah T. Arron, Chase M. Heaton, Joseph DeRisi, Andrew P. South and Steven J. Wang

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:47

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  37. Content type: Original research article

    Mental practice, the cognitive rehearsal of a task in the absence of overt physical movement, has been successfully used in teaching complex psychomotor tasks including sports and music, and recently, surgical...

    Authors: Anne Conlin, Jane Lea, Manohar Bance, Neil Chadha, Shaun Kilty, Frederick Kozak, Julian Savage, Ravindar Sidhu, Joseph Chen and Brian D. Westerberg

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:46

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  38. Content type: Original research article

    The Skull Base Inventory (SBI) was developed to assess the quality of life of patients undergoing endoscopic or open approaches for anterior and central skull base pathologies. In this study, we sought to esta...

    Authors: Soroush Larjani, Eric Monteiro, Ian Witterick, Allan Vescan, Gelareh Zadeh, Fred Gentili, David P. Goldstein and John R. de Almeida

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:45

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  39. Content type: Original research article

    Gas pressure balance is essential for maintaining normal middle ear function. The mucosal surfaces of the middle ear, the mastoid air cell system (MACS), and the Eustachian tube (ET) play a critical role in th...

    Authors: James Belyea, Brandon Wickens and Manohar Bance

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:44

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  40. Content type: Original research article

    Obstructive sleep apnea (OSA) is a common disorder, and continuous airway positive pressure (CPAP) is considered to be the gold standard of therapy. CPAP however is known to have problems with adherence, with ...

    Authors: Brian W. Rotenberg, Dorian Murariu and Kenny P. Pang

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:43

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  41. Content type: Original research article

    The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total/partial laryngectomies, and concurrent radiation chemotherapy for patients with early lar...

    Authors: R. J. De Santis, I. Poon, J. Lee, I. Karam, D. J. Enepekides and K. M. Higgins

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:42

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  42. Content type: Case report

    Gastric pull up remains a popular reconstructive option for pharyngoesophagectomy defects extending to thoracic inlet. Gastric necrosis is a dreaded complication of gastric pull up reconstruction and few studi...

    Authors: Oleksandr Butskiy, Donald W. Anderson and Eitan Prisman

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:41

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  43. Content type: Original research article

    Total laryngectomy (TL) is an appropriate oncologic operation for many patients with laryngeal cancer delivering excellent oncologic outcomes, however it remains beset with significant functional consequences....

    Authors: A. Foreman, R. J. De Santis, F. Sultanov, D. J. Enepekides and K. M. Higgins

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:40

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  44. Content type: Original research article

    Cervical and ocular vestibular evoked myogenic potentials (c/oVEMPs) reflect otolith function. Up-to-date, there are no published reports on the systemic evaluation of otolith function in Ménière’s Disease (MD...

    Authors: Liang Chen, Hui Xu, Wu-qing Wang, Qing-quan Zhang, Qiao-ying Lv and Xi-cheng Song

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:39

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  45. Content type: Original research article

    Many Canadians are affected by sensorineural hearing loss (SNHL) and those with severe or profound hearing loss may have poor hearing function despite optimized hearing aids. Cochlear implants (CI) offer effec...

    Authors: Gavin J. le Nobel, Euna Hwang, Adrian Wu, Sharon Cushing and Vincent Y. Lin

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:38

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  46. Content type: Original research article

    Sonotubometry is a non-invasive means of assessing Eustachian tube (ET) function. Its interpretation remains a complex task with questionable results due to wide variation between trials. A study was conducted...

    Authors: Yaw Amoako-Tuffour, Philip Garland and Manohar Bance

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:37

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  47. Content type: Original research article

    Patients with chronic rhinosinusitis (CRS) often have to endure significant wait times for endoscopic sinus surgery (ESS). The pyschiatric impact of placement on a waitlist for ESS has not been explored.

    Authors: Gordon Fung-Zak Tsang, Carmen L. McKnight, Laura Minhui Kim and John M. Lee

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:36

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  48. Content type: How I do it article

    Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to d...

    Authors: Sabin Filimon, Keith Richardson, Michael P. Hier, Michael Roskies and Alex M. Mlynarek

    Citation: Journal of Otolaryngology - Head & Neck Surgery 2016 45:35

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