Articles

The effectiveness of topical colloidal silver in recalcitrant chronic rhinosinusitis: a randomized crossover control trial

Recalcitrant chronic rhinosinusitis without polyposis (CRSsP) is a challenging condition to manage as traditional medical therapies and surgery fail to provide satisfactory clinical improvements. Colloidal sil...

Authors: John R. Scott, Rohin Krishnan, Brian W. Rotenberg and Leigh J Sowerby

Noise exposure while commuting in Toronto - a study of personal and public transportation in Toronto

With an increasing proportion of the population living in cities, mass transportation has been rapidly expanding to facilitate the demand, yet there is a concern that mass transit has the potential to result i...

Authors: Christopher M.K.L. Yao, Andrew K. Ma, Sharon L. Cushing and Vincent Y.W. Lin

Safety of transtympanic application of probiotics in a chinchilla animal model

Chronic suppurative otitis media can be recalcitrant and difficult to treat, particularly with the increasing occurrence of antibiotic resistance. Lactobacillus plantarum is a probiotic that has been shown to dec...

Authors: Carol Nhan, Aren Bezdjian, Shyamali Saha, Satya Prakash, Lily H. P. Nguyen and Sam J. Daniel

Practices regarding human Papillomavirus counseling and vaccination in head and neck cancer: a Canadian physician questionnaire

Human papillomavirus (HPV) has recently been implicated as a causative agent in a rapidly growing number of oropharyngeal cancers. Emerging literature supports the hypothesis that HPV vaccination may protect a...

Authors: Scott Anderson, Andre Isaac, Caroline C. Jeffery, Joan L. Robinson, Daniela Migliarese Isaac, Christina Korownyk, Vincent L. Biron and Hadi Seikaly

Subtotal Parathyroidectomy and Relocation of the Parathyroid Remnant for Renal Hyperparathyroidism: modification of a traditional operation

We describe a modification of the conventional subtotal parathyroidectomy operation where the parathyroid gland(s) remnant is repositioned with intact vascular supply to a plane superficial to the infrahyoid s...

Authors: Tsu-Hui ( Hubert) Low and John Yoo

Correction to: Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network

Authors: Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay…

Topical propranolol improves epistaxis in patients with hereditary hemorrhagic telangiectasia - a preliminary report

Severe epistaxis is often difficult to control in patients with hereditary hemorrhagic telangiectasia (HHT). Propranolol has been shown to have antiangiogenic properties in vitro and in vivo and is commonly us...

Authors: Meir Mei-Zahav, Hannah Blau, Elchanan Bruckheimer, Eyal Zur and Neta Goldschmidt

Paradigm shift in head and neck oncology patient management

This article describes a paradigm shift in what is considered to be good care for patients living with and after (head and neck) cancer. HNO patients often experience severe and difficult physical and psychoso...

Authors: Chiquit van Linden van den Heuvell, Florence van Zuuren, Mary Wells, Geert van der Laan and Harry Reintsema

Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network

While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their c...

Authors: Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay…

Evolution of gender representation among Canadian OTL-HNS residents: a 27-year analysis

The proportion of females enrolling into medical schools has been growing steadily. However, the representation of female residents among individual specialties has shown considerable variation. The purpose of...

Authors: Sarah Chorfi, Joseph S. Schwartz, Neil Verma, Meredith Young, Lawrence Joseph and Lily H. P. Nguyen

Peri-operative factors predisposing to pharyngocutaneous fistula after total laryngectomy: analysis of a large multi-institutional patient cohort

Pharyngocutaneous fistula (PCF) is a problematic complication following total laryngectomy. Disagreement remains regarding predisposing factors. This study examines perioperative factors predicting PCF followi...

Authors: Nicole L. Lebo, Lisa Caulley, Hussain Alsaffar, Martin J. Corsten and Stephanie Johnson-Obaseki

Endoscopically-assisted transmastoid approach to the geniculate ganglion and labyrinthine facial nerve

Endoscopic transcanal approaches to the facial nerve allow excellent exposure of the tympanic facial nerve. This approach becomes limited when access is required to the more proximal geniculate ganglion and la...

Authors: Nicholas Jufas and Manohar Bance

Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differen...

Authors: Robert E. Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek and Ron J. Karni

Otolaryngology exposure in a longitudinal integrated clerkship setting

Although 20–40% of primary care complaints are Otolaryngology-Head and Neck Surgery (OtoHNS) related, little emphasis is placed on OtoHNS instruction at the undergraduate medical education level. An OtoHNS cle...

Authors: Grace Margaret Scott, Corliss Ann Elizabeth Best and Damian Christopher Micomonaco

Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss

Only few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). Little is known about the efficacy of second-line therapies. Rheopheresis seems to be an ef...

Authors: Milan Kostal, Jakub Drsata, Milan Bláha, Miriam Lánská and Viktor Chrobok

PTH monitoring after total parathyroidectomy with forearm auto-transplantation: potential for spuriously high levels from grafted forearm

We have identified a cause of falsely elevated parathyroid hormone (PTH) levels after total parathyroidectomy with forearm auto-transplantation (TPT-ATx). Our cases highlight the need to draw PTH samples remot...

Authors: Diana Khalil and Paul D. Kerr

The palisade cartilage tympanoplasty technique: a systematic review and meta-analysis

Tympanoplasty is a common procedure performed by Otolaryngologists. Many types of autologous grafts have been used with variations of techniques with varying results. This is the first systematic review of the...

Authors: Caroline C. Jeffery, Cameron Shillington, Colin Andrews and Allan Ho

Transmission of a novel sonotubometry acoustic click stimulus in healthy and patulous eustachian tube subjects: a retrospective case -control study

Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowin...

Authors: Justin M. Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B. Butler and Manohar Bance

Direct cost comparison of minimally invasive punch technique versus traditional approaches for percutaneous bone anchored hearing devices

Minimally Invasive Ponto Surgery (MIPS) was recently described as a new technique to facilitate the placement of percutaneous bone anchored hearing devices.

Authors: Yaeesh Sardiwalla, Nicholas Jufas and David P. Morris

Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection

Head and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is...

Authors: Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács and Eva Hammerlid

Effect of cochlear implant surgery on vestibular function: meta-analysis study

Vestibular disorders have been reported following cochlear implant (CI) surgery, but the literature shows a wide discrepancy in the reported clinical impact. The aim of this meta-analysis is to quantify the ef...

Authors: Iman Ibrahim, Sabrina Daniela da Silva, Bernard Segal and Anthony Zeitouni

Patterns of regional recurrence in papillary thyroid cancer patients with lateral neck metastases undergoing neck dissection

Practice variability exists for the extent of neck dissection undertaken for papillary thyroid carcinoma (PTC) metastatic to the lateral neck nodes, with disagreement over routine level V dissection.

Authors: Jason J. Xu, Eugene Yu, Caitlin McMullen, Jesse Pasternak, Jim Brierley, Richard Tsang, Han Zhang, Antoine Eskander, Lorne Rotstein, Anna M. Sawka, Ralph Gilbert, Jonathan Irish, Patrick Gullane, Dale Brown, John R. de Almeida and David P. Goldstein

Identifying high quality medical education websites in Otolaryngology: a guide for medical students and residents

Learners often utilize online resources to supplement formalized curricula, and to appropriately support learning, these resources should be of high quality. Thus, the objectives of this study are to develop ...

Authors: Nathan Yang, Sarah Hosseini, Marco A. Mascarella, Meredith Young, Nancy Posel, Kevin Fung and Lily H. P. Nguyen

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure to...

Authors: Trung N. Le, Louise V. Straatman, Jane Lea and Brian Westerberg

Cochlear implant electrode sealing techniques and related intracochlear pressure changes

The inserted cochlear implanted electrode is covered at the site of the round window or cochleostomy to prevent infections and leakage. In a surgically hearing preservational concept, low intracochlear pressur...

Authors: Ingo Todt, Julica Utca, Dania Karimi, Arne Ernst and Philipp Mittmann

Management delays in patients with squamous cell cancer of neck node(s) and unknown primary site: a retrospective cohort study

We aim to characterize the workup received by and identify any delays to diagnosis or treatment in patients referred to a tertiary cancer centre with the diagnosis of squamous cell carcinoma in neck node(s) an...

Authors: Kevin Martell, Joanna Mackenzie, Warren Kerney and Harold Yeehau Lau

Development and validation of an administrative data algorithm to identify adults who have endoscopic sinus surgery for chronic rhinosinusitis

This was a diagnostic accuracy study to develop an algorithm based on administrative database codes that identifies patients with Chronic Rhinosinusitis (CRS) who have endoscopic sinus surgery (ESS).

Authors: Kristian I. Macdonald, Shaun J. Kilty and Carl van Walraven

Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing

Adenotonsillectomy (AT) is the most commonly performed procedure for sleep disordered breathing (SDB) in pediatrics. However, 20-40% of patients will have persistent signs and symptoms of SDB after AT. Drug-in...

Authors: Noura Alsufyani, Andre Isaac, Manisha Witmans, Paul Major and Hamdy El-Hakim

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

Eosinophilic chronic frontal sinusitis is difficult to treat compared with non-eosinophilic sinusitis because of recurring inflammation and polyp formation in the frontal recess after the post-operative follow...

Authors: Kazunori Kubota, Sachio Takeno, Takayuki Taruya, Atsushi Sasaki, Takashi Ishino and Katsuhiro Hirakawa

Maxillofacial prosthodontics practice profile: a survey of non-United States prosthodontists

This study surveyed non-United States maxillofacial prosthodontists (MFP) to determine their practice profile and rationale for pursuing an MFP career.

Authors: Nina Ariani, Harry Reintsema, Kathleen Ward, Cortino Sukotjo and Alvin G. Wee

Does medical school research productivity predict a resident’s research productivity during residency?

Research productivity is an important component of the CanMEDS Scholar role and is an accreditation requirement of Canadian Otolaryngology training programs. Our objective was to determine if an association ex...

Authors: Scott Kohlert, Laura Zuccaro, Laurie McLean and Kristian Macdonald

Comparison of the mechanical properties of different skin sites for auricular and nasal reconstruction

Autologous and synthetic nasal and auricular frameworks require skin coverage. The surgeon’s decides on the appropriate skin coverage for reconstruction based on colour matching, subcutaneous tissue thickness,...

Authors: M. F. Griffin, B. C. Leung, Y. Premakumar, M. Szarko and P. E. Butler

Factors associated with lingual tonsil hypertrophy in Canadian adults

Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adul...

Authors: Matthew S. Harris, Brian W. Rotenberg, Kathryn Roth and Leigh J. Sowerby

Using cone beam CT to assess the upper airway after surgery in children with sleep disordered breathing symptoms and maxillary-mandibular disproportions: a clinical pilot

The surgical excision of anatomic obstructions such as adenoids, palatine or lingual tonsils are commonly performed in children with sleep disordered breathing (SDB). Imaging studies measuring airway changes p...

Authors: Noura A. Alsufyani, Michelle L. Noga, Manisha Witmans, Irene Cheng, Hamdy El-Hakim and Paul W. Major

Surgical site infections following oral cavity cancer resection and reconstruction is a risk factor for plate exposure

Plate-related complications following head and neck cancer ablation and reconstruction remains a challenging problem often requiring further management and reconstructive surgeries. We aim to identify an assoc...

Authors: Christopher M. Yao, Hedyeh Ziai, Gordon Tsang, Andrea Copeland, Dale Brown, Jonathan C. Irish, Ralph W. Gilbert, David P. Goldstein, Patrick J. Gullane and John R. de Almeida

Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review

To review the available evidence and make recommendations regarding use of systemically administered drugs in combination or in sequence with radiation (RT) and/or surgery for cure and/or organ preservation in...

Authors: Eric Winquist, Chika Agbassi, Brandon M. Meyers, John Yoo and Kelvin K. W. Chan

The T4/T3 quotient as a risk factor for differentiated thyroid cancer: a case control study

The incidence of thyroid nodules is increasing among patients in North America. Few of these nodules harbour malignancy, thus further research is required to identify predictive markers of malignant thyroid di...

Authors: Mark Sasson, Emily Kay-Rivest, Rami Shoukrun, Anca Florea, Michael Hier, Veronique-Isabelle Forest, Michael Tamilia and Richard J. Payne

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

Sudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient’s social and relational life. The underlying pathomechanisms have not been finally clarified yet and outcome is not pre...

Authors: Daniel Weiss, Armin Julius Böcker, Mario Koopmann, Eleftherios Savvas, Matthias Borowski and Claudia Rudack

A large giant cell tumor of the larynx: case report and review of the literature

Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in t...

Authors: Andrew Arndt, Rachelle LeBlanc and Peter Spafford

The first Canadian experience with the Afirma® gene expression classifier test

Thyroid nodules are common and often benign, although prove to be malignant upon surgical pathology in 5–15% of cases. When assessed with ultrasound-guided fine-needle aspiration (USFNA), 15–30% of the nodules...

Authors: Emily Kay-Rivest, Jamie Tibbo, Sarah Bouhabel, Michael Tamilia, Rebecca Leboeuf, Veronique-Isabelle Forest, Michael P. Hier, Loren Savoury and Richard J. Payne

Can floseal™ be applied safely during otologic surgery? Assessment of ototoxicity in a chinchilla animal model

In otologic surgery good visualization is paramount, and patients with bleeding diatheses or who need to be anti-coagulated can present a significant challenge. Here, we determine whether Floseal™, a hemostati...

Authors: Carol Nhan, Aren Bezdjian, Abdullah Alarfaj and Sam J. Daniel

Incidence and burden of comorbid pain and depression in patients with chronic rhinosinusitis awaiting endoscopic sinus surgery in Canada

This study sheds important light on the association between sino-nasal symptoms and global quality of life in patients with chronic rhinosinusitis waiting for endoscopic sinus surgery. Using patient-reported i...

Authors: Bassem M. N. Hanna, R. Trafford Crump, Guiping Liu, Jason M. Sutherland and Arif S. Janjua

Thyroid incidentalomas on 18FDG-PET/CT: a metabolico-pathological correlation

Thyroid incidentaloma is defined as an unsuspected thyroid lesion found on imaging study or while performing a surgery non-related to the thyroid gland. Most recent scientific literature tends to demonstrate a...

Authors: N. Hagenimana, J. Dallaire, É. Vallée and M. Belzile

Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients

FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infectio...

Authors: Tack-Kyun Kwon, Eun Jae Chung, Nuri Lee, Eun Youn Roh and Eun Young Song

Transoral robotic surgery with radial forearm free flap reconstruction: case control analysis

The resection of large oropharyngeal tumors traditionally involves a lip-splitting mandibulotomy for adequate margin visualization and free flap reconstruction of the surgical defect. Transoral robotic surgery...

Authors: Vincent L. Biron, Daniel A. O’Connell, Brittany Barber, Jessica M. Clark, Colin Andrews, Caroline C. Jeffery, David W. J. Côté, Jeffrey Harris and Hadi Seikaly

Measuring Cochlear Duct Length – a historical analysis of methods and results

Cochlear Duct Length (CDL) has been an important measure for the development and advancement of cochlear implants. Emerging literature has shown CDL can be used in preoperative settings to select the proper si...

Authors: Robert W. Koch, Hanif M. Ladak, Mai Elfarnawany and Sumit K. Agrawal

Mobile tablet audiometry in fluctuating autoimmune ear disease

Autoimmune inner ear disease (AIED) is a rare condition characterized by bilateral fluctuating sensorineural hearing loss (SNHL). The labile nature of this hearing loss makes it difficult to accurately quantif...

Authors: Scott Kohlert and Matthew Bromwich

Tumor-to-tumor metastases: papillary thyroid carcinoma into a clear cell renal cell carcinoma

Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8–3.8% for papillary and 6–20...

Authors: Jin Soo Andy Song, S. Mark Taylor, Jonathan Trites, Matthew H. Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon and Robert D. Hart

Securing an OTL-HNS residency: how competitive is it? Comparing medical student perceptions to actual Canadian statistics

The residency match is an important event in an aspiring physician’s career. Otolaryngology – Head and Neck Surgery (OTL-HNS) is a surgical specialty that has enjoyed high numbers of applicants to its residenc...

Authors: E. Kay-Rivest, N. Varma, G. M. Scott, J. J. Manoukian, M. Desrosiers, J. P. Vaccani and L. H. P. Nguyen

The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma

HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. ...

Authors: Faisal Alzahrani, Leanne Clattenburg, Shanmugam Muruganandan, Martin Bullock, Kaitlyn MacIsaac, Michael Wigerius, Blair A. Williams, M. Elise R. Graham, Matthew H. Rigby, Jonathan R. B. Trites, S. Mark Taylor, Christopher J. Sinal, James P. Fawcett and Robert D. Hart