Articles

Differences in gene expression profile between vocal cord Leukoplakia and normal larynx mucosa by gene chip

Long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. Vocal cord leukoplakia is a precancerous lesion in otolaryngological practice. Till now, the expression patterns and functions of lncRNAs...

Authors: Jianhua Peng, He Li, Jun Chen, Xianming Wu, Tao Jiang and Xiaoyun Chen

Cavernous sinus involvement is not a risk factor for the primary tumor site treatment outcome of Sinonasal adenoid cystic carcinoma

Sinonasal adenoid cystic carcinoma is a rare malignancy of the head and neck. Cavernous sinus invasion from sinonasal adenoid cystic carcinoma and its related management have rarely been investigated. This stu...

Authors: Yi-Chan Lee, Ta-Jen Lee, Ngan-Ming Tsang, Yenlin Huang, Cheng-Lung Hsu, Li-Jen Hsin, Yi-Hsuan Lee and Kai-Ping Chang

Cochlear implants and 1.5 T MRI scans: the effect of diametrically bipolar magnets and screw fixation on pain

The probability that a patient will need an MRI scan at least once in a lifetime is high. However, MRI scanning in cochlear implantees is associated with side effects. Moreover, MRI scan-related artifacts, dis...

Authors: Ingo Todt, Grit Rademacher, Gloria Grupe, Andreas Stratmann, Arne Ernst, Sven Mutze and Philipp Mittmann

Renal protective effect of a hydration supplemented with magnesium in patients receiving cisplatin for head and neck cancer

Our study analyzes the effect of magnesium supplementation on nephrotoxicity in patients receiving cisplatin for head and neck cancer.

Authors: Takahiro Kimura, Taijiro Ozawa, Nobuhiro Hanai, Hitoshi Hirakawa, Hidenori Suzuki, Hiroshi Hosoi and Yasuhisa Hasegawa

Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature

Muckle-Wells syndrome (MWS) is a rare auto-inflammatory disease characterized by the presence of recurrent urticaria, deafness and amyloidosis. Progressive sensorineural hearing loss (SNHL) is reported to occu...

Authors: Cinzia Marchica, Faisal Zawawi, Dania Basodan, Rosie Scuccimarri and Sam J. Daniel

The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature

HPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the pediatric population remai...

Authors: Monika Wojtera, Josee Paradis, Murad Husein, Anthony C. Nichols, John W. Barrett, Marina I. Salvadori and Julie E. Strychowsky

Intraoperative Brief Electrical Stimulation of the Spinal Accessory Nerve (BEST SPIN) for prevention of shoulder dysfunction after oncologic neck dissection: a double-blinded, randomized controlled trial

Shoulder dysfunction is common after neck dissection for head and neck cancer (HNC). Brief electrical stimulation (BES) is a novel technique that has been shown to enhance neuronal regeneration after nerve inj...

Authors: Brittany Barber, Hadi Seikaly, K. Ming Chan, Rhys Beaudry, Shannon Rychlik, Jaret Olson, Matthew Curran, Peter Dziegielewski, Vincent Biron, Jeffrey Harris, Margaret McNeely and Daniel O’Connell

Does hyperthyroidism worsen prognosis of thyroid carcinoma? A retrospective analysis on 2820 consecutive thyroidectomies

Hyperthyroidism is associated with high incidence of thyroid carcinoma; furthermore, tumors arisen in hyperthyroid tissue show an aggressive behavior. Thyroid Stimulating Hormone (TSH) and Thyroid-stimulating ...

Authors: Fabio Medas, Ernico Erdas, Gian Luigi Canu, Alessandro Longheu, Giuseppe Pisano, Massimiliano Tuveri and Pietro Giorgio Calò

An automated A-value measurement tool for accurate cochlear duct length estimation

There has been renewed interest in the cochlear duct length (CDL) for preoperative cochlear implant electrode selection and postoperative generation of patient-specific frequency maps. The CDL can be estimated...

Authors: John E. Iyaniwura, Mai Elfarnawany, Hanif M. Ladak and Sumit K. Agrawal

Clinical implications of the BRAF mutation in papillary thyroid carcinoma and chronic lymphocytic thyroiditis

The purpose of this study was to examine the possible prognostics and clinicopathologic characteristics underlying the BRAFV600E mutation and papillary thyroid carcinoma (PTC) coexisting or in absence of chron...

Authors: Woon Won Kim, Tae Kwun Ha and Sung Kwon Bae

Management of Persistent Epistaxis Using Floseal Hemostatic Matrix vs. traditional nasal packing: a prospective randomized control trial

Epistaxis is the most common emergent consultation to otolaryngology-head & neck surgery (OHNS) and with 60% of the population having experienced an episode and 1.6 in 10,000 requiring hospitalization in their...

Authors: Scott Murray, Adrian Mendez, Alexander Hopkins, Hamdy El-Hakim, Caroline C. Jeffery and David W. J. Côté

Head and Neck Surgical Oncology Choosing Wisely Campaign: imaging for patients with hoarseness, fine needle aspiration for neck mass, and ultrasound for odynophagia

Choosing Wisely Canada, is a campaign designed to raise awareness regarding inappropriate or unnecessary tests and treatments. The Canadian Society of Otolaryngology - Head & Neck Surgery and the Canadian Asso...

Authors: Antoine Eskander, Eric Monteiro, Dan O’Connell and S. Mark Taylor

Delayed facial nerve decompression for severe refractory cases of Bell’s palsy: a 25-year experience

This study aims to assess the effectiveness of delayed facial nerve decompression for Bell’s palsy (BP).

Authors: Ilyes Berania, Mohamed Awad, Issam Saliba, Jean-Jacques Dufour and Marc-Elie Nader

Improving learning and confidence through small group, structured otoscopy teaching: a prospective interventional study

Otologic diseases are common and associated with significant health care costs. While accurate diagnosis relies on physical exam, existing studies have highlighted a lack of comfort among trainees with regards...

Authors: Peng You, Saad Chahine and Murad Husein

Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up

Our aim was to review our management of inverted papilloma (IP), perform a recurrence analysis, and review the literature.

Authors: Oisín Bugter, Dominiek André Monserez, Floris Vincent Willem Joseph van Zijl, Robert Jan Baatenburg de Jong and Jose Angelito Hardillo

Mannitol and the blood-labyrinth barrier

Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically diffi...

Authors: Trung N. Le and Brian W. Blakley

Clinical predictors of chronic rhinosinusitis: do the Canadian clinical practice guidelines for acute and chronic rhinosinusitis predict CT-confirmation of disease?

The diagnosis of chronic rhinosinusitis (CRS) based on clinical presentation alone remains challenging. To improve the accuracy of clinical diagnosis, the Canadian Rhinosinusitis Guidelines recommend the use o...

Authors: Paige Moore, Brian Blakley and Eric Meen

The effectiveness of topical colloidal silver in recalcitrant chronic rhinosinusitis: a randomized crossover control trial

Recalcitrant chronic rhinosinusitis without polyposis (CRSsP) is a challenging condition to manage as traditional medical therapies and surgery fail to provide satisfactory clinical improvements. Colloidal sil...

Authors: John R. Scott, Rohin Krishnan, Brian W. Rotenberg and Leigh J Sowerby

Noise exposure while commuting in Toronto - a study of personal and public transportation in Toronto

With an increasing proportion of the population living in cities, mass transportation has been rapidly expanding to facilitate the demand, yet there is a concern that mass transit has the potential to result i...

Authors: Christopher M.K.L. Yao, Andrew K. Ma, Sharon L. Cushing and Vincent Y.W. Lin

Safety of transtympanic application of probiotics in a chinchilla animal model

Chronic suppurative otitis media can be recalcitrant and difficult to treat, particularly with the increasing occurrence of antibiotic resistance. Lactobacillus plantarum is a probiotic that has been shown to dec...

Authors: Carol Nhan, Aren Bezdjian, Shyamali Saha, Satya Prakash, Lily H. P. Nguyen and Sam J. Daniel

Practices regarding human Papillomavirus counseling and vaccination in head and neck cancer: a Canadian physician questionnaire

Human papillomavirus (HPV) has recently been implicated as a causative agent in a rapidly growing number of oropharyngeal cancers. Emerging literature supports the hypothesis that HPV vaccination may protect a...

Authors: Scott Anderson, Andre Isaac, Caroline C. Jeffery, Joan L. Robinson, Daniela Migliarese Isaac, Christina Korownyk, Vincent L. Biron and Hadi Seikaly

Subtotal Parathyroidectomy and Relocation of the Parathyroid Remnant for Renal Hyperparathyroidism: modification of a traditional operation

We describe a modification of the conventional subtotal parathyroidectomy operation where the parathyroid gland(s) remnant is repositioned with intact vascular supply to a plane superficial to the infrahyoid s...

Authors: Tsu-Hui ( Hubert) Low and John Yoo

Correction to: Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network

Authors: Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay…

Topical propranolol improves epistaxis in patients with hereditary hemorrhagic telangiectasia - a preliminary report

Severe epistaxis is often difficult to control in patients with hereditary hemorrhagic telangiectasia (HHT). Propranolol has been shown to have antiangiogenic properties in vitro and in vivo and is commonly us...

Authors: Meir Mei-Zahav, Hannah Blau, Elchanan Bruckheimer, Eyal Zur and Neta Goldschmidt

Paradigm shift in head and neck oncology patient management

This article describes a paradigm shift in what is considered to be good care for patients living with and after (head and neck) cancer. HNO patients often experience severe and difficult physical and psychoso...

Authors: Chiquit van Linden van den Heuvell, Florence van Zuuren, Mary Wells, Geert van der Laan and Harry Reintsema

Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network

While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their c...

Authors: Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay…

Evolution of gender representation among Canadian OTL-HNS residents: a 27-year analysis

The proportion of females enrolling into medical schools has been growing steadily. However, the representation of female residents among individual specialties has shown considerable variation. The purpose of...

Authors: Sarah Chorfi, Joseph S. Schwartz, Neil Verma, Meredith Young, Lawrence Joseph and Lily H. P. Nguyen

Peri-operative factors predisposing to pharyngocutaneous fistula after total laryngectomy: analysis of a large multi-institutional patient cohort

Pharyngocutaneous fistula (PCF) is a problematic complication following total laryngectomy. Disagreement remains regarding predisposing factors. This study examines perioperative factors predicting PCF followi...

Authors: Nicole L. Lebo, Lisa Caulley, Hussain Alsaffar, Martin J. Corsten and Stephanie Johnson-Obaseki

Endoscopically-assisted transmastoid approach to the geniculate ganglion and labyrinthine facial nerve

Endoscopic transcanal approaches to the facial nerve allow excellent exposure of the tympanic facial nerve. This approach becomes limited when access is required to the more proximal geniculate ganglion and la...

Authors: Nicholas Jufas and Manohar Bance

Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differen...

Authors: Robert E. Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek and Ron J. Karni

Otolaryngology exposure in a longitudinal integrated clerkship setting

Although 20–40% of primary care complaints are Otolaryngology-Head and Neck Surgery (OtoHNS) related, little emphasis is placed on OtoHNS instruction at the undergraduate medical education level. An OtoHNS cle...

Authors: Grace Margaret Scott, Corliss Ann Elizabeth Best and Damian Christopher Micomonaco

Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss

Only few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). Little is known about the efficacy of second-line therapies. Rheopheresis seems to be an ef...

Authors: Milan Kostal, Jakub Drsata, Milan Bláha, Miriam Lánská and Viktor Chrobok

PTH monitoring after total parathyroidectomy with forearm auto-transplantation: potential for spuriously high levels from grafted forearm

We have identified a cause of falsely elevated parathyroid hormone (PTH) levels after total parathyroidectomy with forearm auto-transplantation (TPT-ATx). Our cases highlight the need to draw PTH samples remot...

Authors: Diana Khalil and Paul D. Kerr

The palisade cartilage tympanoplasty technique: a systematic review and meta-analysis

Tympanoplasty is a common procedure performed by Otolaryngologists. Many types of autologous grafts have been used with variations of techniques with varying results. This is the first systematic review of the...

Authors: Caroline C. Jeffery, Cameron Shillington, Colin Andrews and Allan Ho

Transmission of a novel sonotubometry acoustic click stimulus in healthy and patulous eustachian tube subjects: a retrospective case -control study

Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowin...

Authors: Justin M. Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B. Butler and Manohar Bance

Direct cost comparison of minimally invasive punch technique versus traditional approaches for percutaneous bone anchored hearing devices

Minimally Invasive Ponto Surgery (MIPS) was recently described as a new technique to facilitate the placement of percutaneous bone anchored hearing devices.

Authors: Yaeesh Sardiwalla, Nicholas Jufas and David P. Morris

Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection

Head and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is...

Authors: Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács and Eva Hammerlid

Effect of cochlear implant surgery on vestibular function: meta-analysis study

Vestibular disorders have been reported following cochlear implant (CI) surgery, but the literature shows a wide discrepancy in the reported clinical impact. The aim of this meta-analysis is to quantify the ef...

Authors: Iman Ibrahim, Sabrina Daniela da Silva, Bernard Segal and Anthony Zeitouni

Patterns of regional recurrence in papillary thyroid cancer patients with lateral neck metastases undergoing neck dissection

Practice variability exists for the extent of neck dissection undertaken for papillary thyroid carcinoma (PTC) metastatic to the lateral neck nodes, with disagreement over routine level V dissection.

Authors: Jason J. Xu, Eugene Yu, Caitlin McMullen, Jesse Pasternak, Jim Brierley, Richard Tsang, Han Zhang, Antoine Eskander, Lorne Rotstein, Anna M. Sawka, Ralph Gilbert, Jonathan Irish, Patrick Gullane, Dale Brown, John R. de Almeida and David P. Goldstein

Identifying high quality medical education websites in Otolaryngology: a guide for medical students and residents

Learners often utilize online resources to supplement formalized curricula, and to appropriately support learning, these resources should be of high quality. Thus, the objectives of this study are to develop ...

Authors: Nathan Yang, Sarah Hosseini, Marco A. Mascarella, Meredith Young, Nancy Posel, Kevin Fung and Lily H. P. Nguyen

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure to...

Authors: Trung N. Le, Louise V. Straatman, Jane Lea and Brian Westerberg

Cochlear implant electrode sealing techniques and related intracochlear pressure changes

The inserted cochlear implanted electrode is covered at the site of the round window or cochleostomy to prevent infections and leakage. In a surgically hearing preservational concept, low intracochlear pressur...

Authors: Ingo Todt, Julica Utca, Dania Karimi, Arne Ernst and Philipp Mittmann

Management delays in patients with squamous cell cancer of neck node(s) and unknown primary site: a retrospective cohort study

We aim to characterize the workup received by and identify any delays to diagnosis or treatment in patients referred to a tertiary cancer centre with the diagnosis of squamous cell carcinoma in neck node(s) an...

Authors: Kevin Martell, Joanna Mackenzie, Warren Kerney and Harold Yeehau Lau

Development and validation of an administrative data algorithm to identify adults who have endoscopic sinus surgery for chronic rhinosinusitis

This was a diagnostic accuracy study to develop an algorithm based on administrative database codes that identifies patients with Chronic Rhinosinusitis (CRS) who have endoscopic sinus surgery (ESS).

Authors: Kristian I. Macdonald, Shaun J. Kilty and Carl van Walraven

Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing

Adenotonsillectomy (AT) is the most commonly performed procedure for sleep disordered breathing (SDB) in pediatrics. However, 20-40% of patients will have persistent signs and symptoms of SDB after AT. Drug-in...

Authors: Noura Alsufyani, Andre Isaac, Manisha Witmans, Paul Major and Hamdy El-Hakim

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

Eosinophilic chronic frontal sinusitis is difficult to treat compared with non-eosinophilic sinusitis because of recurring inflammation and polyp formation in the frontal recess after the post-operative follow...

Authors: Kazunori Kubota, Sachio Takeno, Takayuki Taruya, Atsushi Sasaki, Takashi Ishino and Katsuhiro Hirakawa

Maxillofacial prosthodontics practice profile: a survey of non-United States prosthodontists

This study surveyed non-United States maxillofacial prosthodontists (MFP) to determine their practice profile and rationale for pursuing an MFP career.

Authors: Nina Ariani, Harry Reintsema, Kathleen Ward, Cortino Sukotjo and Alvin G. Wee

Does medical school research productivity predict a resident’s research productivity during residency?

Research productivity is an important component of the CanMEDS Scholar role and is an accreditation requirement of Canadian Otolaryngology training programs. Our objective was to determine if an association ex...

Authors: Scott Kohlert, Laura Zuccaro, Laurie McLean and Kristian Macdonald

Comparison of the mechanical properties of different skin sites for auricular and nasal reconstruction

Autologous and synthetic nasal and auricular frameworks require skin coverage. The surgeon’s decides on the appropriate skin coverage for reconstruction based on colour matching, subcutaneous tissue thickness,...

Authors: M. F. Griffin, B. C. Leung, Y. Premakumar, M. Szarko and P. E. Butler

Factors associated with lingual tonsil hypertrophy in Canadian adults

Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adul...

Authors: Matthew S. Harris, Brian W. Rotenberg, Kathryn Roth and Leigh J. Sowerby