Articles

HPV Status and second primary tumours in Oropharyngeal Squamous Cell Carcinoma

The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCCs) is rising in developed nations. Studies have shown that these virally mediated tumours are epidemiologically, ...

Authors: Caroline C Xu, Vincent L Biron, Lakshmi Puttagunta and Hadi Seikaly

Use of a Low-fidelity simulator to improve trans-nasal fibre-optic flexible laryngoscopy in the clinical setting: a randomized, single-blinded, prospective study

Trans-nasal flexible fibre-optic laryngoscopy (TFFL) is an essential skill for otolaryngologists. There is evidence to suggest that simulators help residents acquire procedural skills. The objective of this st...

Authors: Michael W Deutschmann, Warren K Yunker, John J Cho, Meri Andreassen, Shari Beveridge and John Douglas Bosch

Vocal cord paralysis secondary to spontaneous internal carotid dissection: case report and systematic review of the literature

To present a rare case of unilateral vocal cord paralysis (VCP) secondary to spontaneous internal carotid artery dissection and to perform a literature review.

Authors: TT Jean Nguyen, Han Zhang, Peter T Dziegielewski and Robert Seemann

Canadian Otolaryngology - Head and Neck Surgery clerkship curricula: evolving toward tomorrow’s learners

Increasing focus is being placed on Clerkship curriculum design and implementation in light of new undergraduate medical education research and accreditation standards. Canadian Otolaryngology-Head and Neck Su...

Authors: Kate Kelly, Kevin Fung and Laurie McLean

Medial Mandibulotomies: Is there sufficient space in the midline to allow a mandibulotomy without compromising the dentition?

The objective of this study was to determine the frequency of complications in median and paramedian mandibulotomies. In addition, the interdental space in the median and paramedian region was calculated.

Authors: Tulika Shinghal, Eric Bissada, Hon Biu Chan, Robert E Wood, Eshetu G Atenafu, Dale H Brown, Ralph W Gilbert, Patrick J Gullane, Jonathan C Irish, John Waldron and David P Goldstein

Primary surgery versus chemoradiotherapy for advanced oropharyngeal cancers: a longitudinal population study

Treatment for advanced stage oropharyngeal squamous cell carcinoma (OPSCC) includes combined chemoradiation therapy or surgery followed by radiation therapy alone or in combination with chemotherapy. The goal ...

Authors: Daniel O’Connell, Hadi Seikaly, Russell Murphy, Charles Fung, Tim Cooper, Aaron Knox, Rufus Scrimger and Jeffrey R Harris

Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy: a multi-institutional analysis

The oral cavity is the most common site for head and neck squamous cell carcinoma. Treatment of advanced stage oral cavity squamous cell carcinoma (OCSCC) has classically involved surgical resection with posto...

Authors: Han Zhang, Peter T Dziegielewski, Vince L Biron, Jacek Szudek, Khaled H Al-Qahatani, Daniel A O’Connell, Jeffrey R Harris and Hadi Seikaly

Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β₁ as compared with healthy nasal mucosa

To evaluate TGF-β₁ expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).

Authors: Leonardo Balsalobre, Rogério Pezato, Claudina Perez-Novo, Maria Teresa S Alves, Rodrigo P Santos, Claus Bachert and Luc LM Weckx

The impact of clinical versus pathological staging in oral cavity carcinoma–a multi-institutional analysis of survival

To evaluate any disparity in clinical versus pathological TNM staging in oral cavity squamous cell carcinoma (OCSCC) patients and any impact of this on survival.

Authors: Vincent L Biron, Daniel A O’Connell and Hadi Seikaly

Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with na...

Authors: Rogério Pezato, Leonardo Balsalobre, Milena Lima, Thiago F P Bezerra, Richard L Voegels, Luis Carlos Gregório, Aldo Cassol Stamm and Thibaut van Zele

MRI findings of radiation-induced changes of masticatory muscles: a systematic review

Radiotherapy to the head and neck regions can result in serious consequences to the temporomandibular joint (TMJ) and chewing muscles. Magnetic resonance imaging (MRI) demonstrates soft-tissue alterations afte...

Authors: Mohammed AQ Al-Saleh, Jacob L Jaremko, Humam Saltaji, John Wolfaardt and Paul W Major

Evaluation of the accuracy of Cone Beam Computerized Tomography (CBCT): medical imaging technology in head and neck reconstruction

With the introduction, development and commercialization of Cone Beam Computerized Tomography (CBCT) technologies in the field of head and neck reconstruction, clinicians now have increased access to the techn...

Authors: Heather Logan, Johan Wolfaardt, Pierre Boulanger, Bill Hodgetts and Hadi Seikaly

Evaluating the timing of injection laryngoplasty for vocal fold paralysis in an attempt to avoid future type 1 thyroplasty

To determine whether immediate (less than 3 months from time of nerve injury), early (from 3 to 6 months from time of nerve injury) or late (more than 6 months from time of nerve injury) vocal fold injection i...

Authors: Yazeed Alghonaim, Michael Roskies, Karen Kost and Jonathan Young

Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer

To determine the biological characteristics of oropharyngeal squamous cell carcinoma (OpSCC) and related outcome.

Authors: Rui Jun Lin, Tarinee Lubpairee, Kelly Y Liu, Donald W Anderson, Scott Durham and Catherine F Poh

Treatment of T1b glottic SCC: laser vs. radiation- a Canadian multicenter study

To assess the oncological and functional outcomes of T1b squamous cell carcinoma (SCC) of the glottic larynx treated with laser in comparison with radiation.

Authors: S Mark Taylor, Paul Kerr, Kevin Fung, Mankavil K Aneeshkumar, Derek Wilke, Yida Jiang, John Scott, Judith Phillips, Robert D Hart, Jonathan RB Trites and Matthew H Rigby

The new age of play audiometry: prospective validation testing of an iPad-based play audiometer

The timely diagnosis of hearing loss in the pediatric population has significant implications for a child’s development. However, audiological evaluation in this population poses unique challenges due to diffi...

Authors: Jeffrey Yeung, Hedyeh Javidnia, Sophie Heley, Yves Beauregard, Sandra Champagne and Matthew Bromwich

Percutaneous endoscopic gastrostomy site metastasis from head and neck squamous cell carcinoma: case series and literature review

To present our experience with head and neck squamous cell carcinoma (HNSCC) seeding of percutaneous endoscopic gastrostomy (PEG) sites and to review all reported cases to identify risk factors and develop str...

Authors: Andrew T Huang, Alexandros Georgolios, Sasa Espino, Brian Kaplan, James Neifeld and Evan R Reiter

Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration

To investigate glucocorticoid uptake in auditory hair cells following transtympanic versus systemic administration of dexamethasone.

Authors: Amandeep S Grewal, Julian M Nedzelski, Joseph M Chen and Vincent YW Lin

Surgical vs ultrasound-guided drainage of deep neck space abscesses: a randomized controlled trial: surgical vs ultrasound drainage

Deep neck space abscesses (DNAs) are relatively common otolaryngology-head and neck surgery emergencies and can result in significant morbidity with potential mortality. Traditionally, surgical incision and dr...

Authors: Vincent L Biron, George Kurien, Peter Dziegielewski, Brittany Barber and Hadi Seikaly

Laser Doppler Vibrometry measurements of human cadaveric tympanic membrane vibration

To determine the feasibility of measuring tympanic membrane (TM) vibrations at multiple locations on the TM to differentiate normal eardrums from those with associated ossicular pathologies.

Authors: Jason A Beyea, Seyed Alireza Rohani, Hanif M Ladak and Sumit K Agrawal

Serum biomarkers of papillary thyroid cancer

To identify serum biomarkers of papillary thyroid cancer.

Authors: Fawaz M Makki, S Mark Taylor, Ali Shahnavaz, Andrew Leslie, Jeffrey Gallant, Susan Douglas, Evelyn Teh, Jonathan Trites, Martin Bullock, Karen Inglis, Devanand M Pinto and Robert D Hart

The incidence of early post-operative complications following uvulopalatopharyngoplasty: identification of predictive risk factors

Characterize complications following uvulopalatopharyngoplasty (UPPP) for obstructive sleep apnea.

Authors: Thileeban Kandasamy, Erin D Wright, John Fuller and Brian W Rotenberg

Prognostic factors for metastatic cutaneous squamous cell carcinoma of the parotid

To explore the prognostic significance of patient and disease characteristics on the survival of patients with metastatic cutaneous squamous cell carcinoma of the parotid gland at a tertiary care center in Hal...

Authors: Fawaz M Makki, Adrian I Mendez, S Mark Taylor, Jonathan Trites, Martin Bullock, Gordon Flowerdew and Robert D Hart

The ototoxic effect of intratympanic terbinafine applied in the middle ear of rats

Otomycosis is defined as an infection of the external ear canal with fungal agents. The treatment of the disease is cleansing and drying of the external ear canal, identification and treatment of any predispos...

Authors: Mustafa Sagit, Mehmet Akıf Somdas, Ferhat Korkmaz and Alper Akcadag

An endonasal approach to the resection of a papillary seromucinous adenocarcinoma of the Eustacian tube

Papillary seromucinous adenocarcinoma of the sinonasal tract is exceedingly rare. The objectives of this case report are to describe a case of papillary seromucinous adenocarcinoma presenting in the nasopharyn...

Authors: Jordan T Glicksman, Jason H Franklin, Jessica Shepherd and Brian W Rotenberg

Fibrolipoma of the nasal septum; report of the first case

Fibrolipomas are a rare subtype of lipomas and very rare in the oral and maxillofacial region. Lipomas affecting the central nervous system are even more infrequent occurring with a frequency of 0.1%.

Authors: Murat Ozturk, Kadri Ila, Ahmet Kara and Mete Iseri

Can otoplasty impact hearing? A prospective randomized controlled study examining the effects of pinna position on speech reception and intelligibility

Otoplasty is a commonly performed surgical procedure that restores the ideal position of the pinna. Although the pinna is a well-recognized component of the auditory apparatus, no studies have assessed the aud...

Authors: Michael L McNeil, Steve J Aiken, Manohar Bance, Jeff R Leadbetter and Paul Hong

Does HPV type affect outcome in oropharyngeal cancer?

An epidemic of human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has been reported worldwide largely due to oral infection with HPV type-16, which is responsible for approximately 9...

Authors: Anthony C Nichols, Sandeep S Dhaliwal, David A Palma, John Basmaji, Corina Chapeskie, Samuel Dowthwaite, Jason H Franklin, Kevin Fung, Keith Kwan, Brett Wehrli, Chris Howlett, Iram Siddiqui, Marina I Salvadori, Eric Winquist, Scott Ernst, Sara Kuruvilla…

Development of a transoral robotic surgery program in Canada

Due to significant differences in healthcare structure between the United States and Canada, there are unique barriers to adopting new medical technology in Canada. In this article, we describe our experience ...

Authors: Anthony C Nichols, Kevin Fung, Corina Chapeskie, Samuel A Dowthwaite, John Basmaji, Sandeep Dhaliwal, Christopher CT Szeto, David A Palma, Julie A Theurer, Martin A Corsten, Michael Odell, John W Barrett, Jason H Franklin and John Yoo

Percutaneous cartilage injection: A prospective animal study on a rabbit model

Cartilage grafting is a useful technique in nasal reconstruction. Implantation of a whole graft is usually done through an incision. Crushed cartilage can also be used. Injection of cartilage could be an alter...

Authors: Olivier X Beaudoin, Andrew Mitchell and Akram Rahal

The inferior turbinate flap in skull base reconstruction

As the indications for expanded endonasal approaches continue to evolve, alternative reconstructive techniques are needed to address increasingly complex surgical skull base defects. In the absence of the naso...

Authors: Jonathan Yip, Kristian I Macdonald, John Lee, Ian J Witterick, Gelareh Zadeh, Fred Gentili and Allan D Vescan

The epidemiology, antibiotic resistance and post-discharge course of peritonsillar abscesses in London, Ontario

Peritonsillar abscesses (PTA) are a common complication of tonsillitis. Recent global epidemiological data regarding PTAs have demonstrated increasing antimicrobial resistance patterns. No similar studies have...

Authors: Leigh J Sowerby, Zafar Hussain and Murad Husein

THREAT helps to identify epistaxis patients requiring blood transfusions

To analyze the characteristics of patients who needed a blood transfusion due to epistaxis-caused anemia and to define potential risk factors.

Authors: Karin Murer, Nader Ahmad, Beatrice A Roth, David Holzmann and Michael B Soyka

Prenatal ultrasound exposure and association with postnatal hearing outcomes

Prenatal ultrasound exams have become increasingly frequent. Although no serious adverse effects are known, the public health implications would be enormous should adverse effects on auditory development be sh...

Authors: Claude F Harbarger, Paul M Weinberger, Jack C Borders and Charles A Hughes

Sinonasal Undifferentiated Carcinoma (SNUC): the Alberta experience and literature review

Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy with often dismal outcomes. This study set to determine provincial and literature-wide survival outcomes based on treatment modality.

Authors: Caroline C Xu, Peter T Dziegielewski, William T McGaw and Hadi Seikaly

Journal of Otolaryngology Head & Neck Surgery – An ‘Open’ Letter to Our Authors and Readers

Authors: Hadi Seikaly and Erin D Wright